Featured Publications
Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy
Chen Y, Li S, Ge W, Jing J, Chen HY, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher CB, Smith C, Maciel CB, Alkhachroum A, Lee JW, Dhakar MB, Gilmore EJ, Sivaraju A, Hirsch LJ, Omay SB, Blumenfeld H, Sheth KN, Struck AF, Edlow BL, Westover MB, Kim JA. Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. Journal Of Neurology Neurosurgery & Psychiatry 2022, 94: 245-249. PMID: 36241423, PMCID: PMC9931627, DOI: 10.1136/jnnp-2022-329542.Peer-Reviewed Original ResearchConceptsPost-traumatic epilepsyTraumatic brain injuryCT abnormalitiesElectroencephalography featuresAdmission Glasgow Coma Scale scoreGlasgow Coma Scale scoreRetrospective case-control studyMultivariable logistic regression analysisRisk stratification modelCase-control studyLogistic regression analysisTBI admissionsSevere complicationsFuture trialsBrain injuryCT reportsSeizure diagnosisPredictive valueScale scorePatientsLogistic regressionStratification modelQuantitative electroencephalogramTBI mechanismsRegression analysisDevelopment and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography Reports
Torres-Lopez VM, Rovenolt GE, Olcese AJ, Garcia GE, Chacko SM, Robinson A, Gaiser E, Acosta J, Herman AL, Kuohn LR, Leary M, Soto AL, Zhang Q, Fatima S, Falcone GJ, Payabvash MS, Sharma R, Struck AF, Sheth KN, Westover MB, Kim JA. Development and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography Reports. JAMA Network Open 2022, 5: e2227109. PMID: 35972739, PMCID: PMC9382443, DOI: 10.1001/jamanetworkopen.2022.27109.Peer-Reviewed Original ResearchConceptsNatural language processingF-scoreTest data setsLanguage processingIndependent test data setsData setsBidirectional Encoder RepresentationsAcute brain injuryLarge data setsHead CTBrain injuryNLP toolsF1 scoreNER modelTransformer architectureClinical textEncoder RepresentationsNLP algorithmNLP modelsCT reportsCustom dictionaryTraining setCross-validation performancePerformance metricsAvailable new toolsFocused Management of Patients With Severe Acute Brain Injury and ARDS
Kim JA, Wahlster S, LaBuzetta JN, Nobleza COS, Johnson NJ, Rubinos C, Malaiyandi D, O'Phelan KH, Mainali S, Sarwal A, Gilmore EJ. Focused Management of Patients With Severe Acute Brain Injury and ARDS. CHEST Journal 2021, 161: 140-151. PMID: 34506794, PMCID: PMC8423666, DOI: 10.1016/j.chest.2021.08.066.Peer-Reviewed Original ResearchConceptsSevere acute brain injuryAcute brain injuryBrain injuryTreatment strategiesHigh-acuity patient populationMainstay of treatmentHypothetical case scenariosSevere ARDSConcurrent diseasesPatient populationTreatment decisionsARDSConcomitant managementLung physiologyTreatment conceptNarrative reviewConcomitant occurrenceSimultaneous managementPatientsCOVID-19 pandemicInjuryNoninvasive monitoringFocused managementPhysiological basisManagement
2024
Prognostic Implications of Early Prediction in Posttraumatic Epilepsy
Chen Y, Cappucci S, Kim J. Prognostic Implications of Early Prediction in Posttraumatic Epilepsy. Seminars In Neurology 2024, 44: 333-341. PMID: 38621706, DOI: 10.1055/s-0044-1785502.Peer-Reviewed Original ResearchPosttraumatic epilepsyTraumatic brain injuryComplication of traumatic brain injuryRisk of posttraumatic epilepsyPosttraumatic epilepsy modelBrain injuryPrognostic implicationsPrognostic informationIncreased morbidityClinical trajectoryTreatment strategiesPatient's clinical trajectoryRisk factorsHigh riskQuantitative prognostic information
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imaging
2021
Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury
Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Barber J, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Lowenstein D, Manley GT, Diaz-Arrastia R, , Badjatia N, Duhaime AC, Feeser VR, Gaudette E, Gopinath S, Keene CD, Korley FK, Madden C, Merchant R, Schnyer D, Zafonte R. Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury. JAMA Network Open 2021, 4: e2140191. PMID: 34964854, PMCID: PMC8717106, DOI: 10.1001/jamanetworkopen.2021.40191.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryGlasgow Coma Scale scorePosttraumatic epilepsyBrief Symptom Inventory-18Positive screening resultsCohort studyBrain injuryScreening resultsGlasgow Outcome Scale Extended scoreScale scoreInitial Glasgow Coma Scale scoreGlasgow Outcome Scale-ExtendedTraumatic Brain Injury (CENTER-TBI) studyProspective cohort studyLong-term outcomesUS trauma centersNegative screening resultsTBI common data elementsBrain Injury StudyHigher BSI scoresAntiepileptogenic therapiesPrimary outcomeTBI cohortIdentified patientsTrauma centerA model of metabolic supply-demand mismatch leading to secondary brain injury
Song JL, Kim JA, Struck AF, Zhang R, Westover MB. A model of metabolic supply-demand mismatch leading to secondary brain injury. Journal Of Neurophysiology 2021, 126: 653-667. PMID: 34232754, PMCID: PMC8815783, DOI: 10.1152/jn.00674.2020.Peer-Reviewed Original ResearchConceptsPrimary brain injurySecondary brain injuryAcute brain injuryBrain injuryExtracellular potassiumAdditional brain injuryAssociation of seizuresIschemic strokeNeurologic insultPreventable complicationsSeizure activityCommon sequalaeTissue hypoxiaMetabolic crisisSeizuresInjuryExcitotoxicityPatientsCommon associationAssociationCurrent practiceExcitotoxityComplicationsHemorrhageIschemiaLow-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349)
Mazurek M, Yuen M, Cahn B, Rosen M, Gobeske K, Gilmore E, Hwang D, Kaddouh F, Kim J, Falcone G, Petersen N, Siner J, Spudich S, Sze G, Kimberly W, Sheth K. Low-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.1349.Peer-Reviewed Original Research
2020
Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients
Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. JAMA Neurology 2020, 78: 41-47. PMID: 32897296, PMCID: PMC7489395, DOI: 10.1001/jamaneurol.2020.3263.Peer-Reviewed Original ResearchIntensive care unit roomsIntensive care settingBrain injuryCare settingsIll patientsNeurological injuryT2 fluid-attenuated inversion recoveryCOVID-19Intensive care unit admissionSingle-center cohort studyIntensive care unit settingUnit roomsYale-New Haven HospitalNasopharyngeal swab resultsCare unit admissionSingle-center seriesBrain imaging findingsIntensive care unitFluid-attenuated inversion recoveryDiffusion-weighted imaging sequencesTraumatic brain injuryClinical care settingsNew Haven HospitalMagnetic resonance imagingConventional magnetic resonance imaging (MRI) systemDetecting Seizures and Epileptiform Abnormalities in Acute Brain Injury
Singla S, Garcia GE, Rovenolt GE, Soto AL, Gilmore EJ, Hirsch LJ, Blumenfeld H, Sheth KN, Omay SB, Struck AF, Westover MB, Kim JA. Detecting Seizures and Epileptiform Abnormalities in Acute Brain Injury. Current Neurology And Neuroscience Reports 2020, 20: 42. PMID: 32715371, PMCID: PMC9353690, DOI: 10.1007/s11910-020-01060-4.Peer-Reviewed Original ResearchConceptsIctal-interictal continuumBrain injuryAcute brain injuryBetter clinical outcomesTraumatic brain injuryRecent FindingsCurrent literatureIncreased morbidityClinical outcomesEpileptiform abnormalitiesEEG findingsMortality riskEEG monitoringEpileptiform patternsPrognostic modelSeizuresClinical settingInjuryLogistical barriersElectroencephalogram studyUse of EEGABIPractical barriersEEG analysisEEGMorbidity
2018
Epileptiform activity in traumatic brain injury predicts post‐traumatic epilepsy
Kim JA, Boyle EJ, Wu AC, Cole AJ, Staley KJ, Zafar S, Cash SS, Westover MB. Epileptiform activity in traumatic brain injury predicts post‐traumatic epilepsy. Annals Of Neurology 2018, 83: 858-862. PMID: 29537656, PMCID: PMC5912971, DOI: 10.1002/ana.25211.Peer-Reviewed Original Research