LETAL, A Tumor-Associated NKG2D Immunoreceptor Ligand, Induces Activation and Expansion of Effector Immune Cells
Conejo-Garcia JR, Benencia F, Courreges MC, Khang E, Zhang L, Mohamed-Hadley A, Vinocur JM, Buckanovich RJ, Thompson CB, Levine B, Coukos G. LETAL, A Tumor-Associated NKG2D Immunoreceptor Ligand, Induces Activation and Expansion of Effector Immune Cells. Cancer Biology & Therapy 2003, 2: 446-451. PMID: 14508119, DOI: 10.4161/cbt.2.4.479.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisCD8-Positive T-LymphocytesColonic NeoplasmsCytotoxicity, ImmunologicFemaleHumansImmunoglobulin GInterferon-gammaInterleukin-2K562 CellsKiller Cells, NaturalLigandsLymphocyte ActivationMiceMice, Inbred C57BLMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KOvarian NeoplasmsReceptors, Antigen, T-CellReceptors, ImmunologicReceptors, Natural Killer CellRNA, MessengerSequence Homology, Amino AcidTretinoinType C PhospholipasesConceptsNK cellsNKG2D ligandsTumor cellsTumor immune surveillanceEffector immune cellsPotent activating receptorT cell receptor activationIFNgamma secretionEffector lymphocytesActivating receptorsIL-2Immune cellsImmune surveillancePeripheral tissuesCytotoxic lymphocytesReceptor activationMRNA expressionNormal tissuesCancer cellsRetinoic acidInduces activationLymphocytesCellsTissueActivation