2017
The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry
Roston TM, Yuchi Z, Kannankeril PJ, Hathaway J, Vinocur JM, Etheridge SP, Potts JE, Maginot KR, Salerno JC, Cohen MI, Hamilton RM, Pflaumer A, Mohammed S, Kimlicka L, Kanter RJ, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Choi SHJ, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Van Petegem F, Sanatani S. The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry. EP Europace 2017, 20: 541-547. PMID: 28158428, PMCID: PMC6059141, DOI: 10.1093/europace/euw389.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCalsequestrinChildDeath, Sudden, CardiacDNA Mutational AnalysisFemaleGenetic MarkersGenetic Predisposition to DiseaseHeredityHumansMaleModels, MolecularMutationPedigreePhenotypePrognosisProtein ConformationRegistriesRetrospective StudiesRisk FactorsRyanodine Receptor Calcium Release ChannelStructure-Activity RelationshipTachycardia, VentricularConceptsCatecholaminergic polymorphic ventricular tachycardiaPolymorphic ventricular tachycardiaCardiac eventsCPVT patientsVentricular tachycardiaLife-threatening cardiac eventsInternational multicentre registrySevere CPVT phenotypeRetrospective cohort studyFirst-degree relativesYears of ageRyanodine receptor 2CPVT phenotypeMulticentre registryCohort studySymptomatic patientsMulticentre studyVentricular arrhythmiasCardiac arrestPrognostic markerReceptor 2Ion channelopathiesClinical phenotypeGenetic spectrumGenotypic spectrum
2015
Catecholaminergic Polymorphic Ventricular Tachycardia in Children
Roston TM, Vinocur JM, Maginot KR, Mohammed S, Salerno JC, Etheridge SP, Cohen M, Hamilton RM, Pflaumer A, Kanter RJ, Potts JE, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Kannankeril PJ, Sanatani S. Catecholaminergic Polymorphic Ventricular Tachycardia in Children. Circulation Arrhythmia And Electrophysiology 2015, 8: 633-642. PMID: 25713214, PMCID: PMC4472494, DOI: 10.1161/circep.114.002217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnti-Arrhythmia AgentsChildDeath, Sudden, CardiacDefibrillators, ImplantableElectric CountershockFemaleHumansMalePatient SelectionPhenotypeRegistriesRetrospective StudiesRisk FactorsSeverity of Illness IndexSympathectomyTachycardia, VentricularTime FactorsTreatment OutcomeConceptsCatecholaminergic polymorphic ventricular tachycardiaPolymorphic ventricular tachycardiaCardiac sympathetic denervationImplantable cardioverter defibrillatorVentricular tachycardiaSympathetic denervationTreatment failureCardioverter defibrillatorΒ-blockersCatecholaminergic polymorphic ventricular tachycardia patientsQuarter of patientsRetrospective cohort studyDevice-related complicationsTreatment failure eventsYears of ageVentricular tachycardia patientsCohort studyStandard therapySymptom onsetSymptomatic presentationCardiac arrestSubtherapeutic dosingTreatment outcomesElectrical stormTachycardia patients
2014
Age‐Dependent Sex Effects on Outcomes After Pediatric Cardiac Surgery
Kochilas LK, Vinocur JM, Menk JS. Age‐Dependent Sex Effects on Outcomes After Pediatric Cardiac Surgery. Journal Of The American Heart Association 2014, 3: e000608. PMID: 24496232, PMCID: PMC3959673, DOI: 10.1161/jaha.113.000608.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsCardiac Surgical ProceduresChi-Square DistributionChildChild, PreschoolFemaleHealth Status DisparitiesHeart Defects, CongenitalHospital MortalityHumansInfantInfant, NewbornLogistic ModelsMaleMultivariate AnalysisNorth AmericaOdds RatioRegistriesRetrospective StudiesRisk FactorsSex FactorsTime FactorsTreatment OutcomeConceptsPediatric cardiac operationsPediatric cardiac surgeryCardiac surgeryCardiac operationsPostsurgical mortalityHigh-risk cardiac operationsPediatric Cardiac Care ConsortiumRisk of deathMonths of lifePotential sex differencesAge-dependent relationshipSurgical yearHospital mortalityUnadjusted mortalityPatient sexWhole cohortHigh-risk operationsCardiovascular diseaseSex effectsCardiovascular stressCare ConsortiumEarly infancyZ-scoreLogistic regressionMortality
2013
Surgical Volume and Center Effects on Early Mortality After Pediatric Cardiac Surgery: 25-Year North American Experience From a Multi-institutional Registry
Vinocur JM, Menk JS, Connett J, Moller JH, Kochilas LK. Surgical Volume and Center Effects on Early Mortality After Pediatric Cardiac Surgery: 25-Year North American Experience From a Multi-institutional Registry. Pediatric Cardiology 2013, 34: 1226-1236. PMID: 23377381, PMCID: PMC4357309, DOI: 10.1007/s00246-013-0633-4.Peer-Reviewed Original ResearchConceptsPediatric cardiac surgerySurgical volumePostoperative mortalityCardiac surgeryOdds ratioCenter effectVolume categoriesHierarchical multivariate logistic regression analysisMultivariate logistic regression analysisPediatric Cardiac Care ConsortiumRisk categoriesStudy periodCenter-specific variationCentres' surgical volumeRisk Adjusted ClassificationRetrospective cohort studyEarly postoperative mortalityMulti-institutional registryOdds of deathCongenital heart surgeryNorth American centersLogistic regression analysisLow-risk operationCohort studyPatient characteristics
2012
Putting the Pediatric Cardiac Care Consortium in Context
Vinocur JM, Moller JH, Kochilas LK. Putting the Pediatric Cardiac Care Consortium in Context. Circulation Cardiovascular Quality And Outcomes 2012, 5: 577-579. PMID: 22811500, DOI: 10.1161/circoutcomes.111.964841.Peer-Reviewed Original ResearchAdolescentAge FactorsCardiac Surgical ProceduresCardiologyChildChild, PreschoolCooperative BehaviorHealth Services ResearchHeart DiseasesHumansInfantInfant, NewbornMulticenter Studies as TopicOutcome Assessment, Health CarePediatricsRegistriesRisk AssessmentRisk FactorsTreatment OutcomeUnited States