2020
First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution
Rao VS, Turner JM, Griffin M, Mahoney D, Asher J, Jeon S, Yoo PS, Boutagy N, Feher A, Sinusas A, Wilson FP, Finkelstein F, Testani JM. First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution. Circulation 2020, 141: 1043-1053. PMID: 31910658, PMCID: PMC7331276, DOI: 10.1161/circulationaha.119.043062.Peer-Reviewed Original ResearchConceptsStandard PD solutionExperimental heart failureHeart failurePD solutionsAdverse eventsPeritoneal dialysisSignificant discomfortSodium removalEnd-stage renal diseaseEnd pointElevated right atrial pressureMaintenance of euvolemiaPrimary end pointSecondary end pointsRight atrial pressureHuman proofLoss of responseSolute removalPorcine experimentsAtrial pressureRenal diseaseLoop diureticsSerum electrolytesHuman studiesPeritoneal membrane
2018
Barriers to Advance Care Planning in End-Stage Renal Disease: Who is to Blame, and What Can be Done?
Kelley AT, Turner J, Doolittle B. Barriers to Advance Care Planning in End-Stage Renal Disease: Who is to Blame, and What Can be Done? The New Bioethics 2018, 24: 150-157. PMID: 29513084, DOI: 10.1080/20502877.2018.1438772.Peer-Reviewed Case Reports and Technical NotesConceptsAdvance care planningCare planningEnd-stage renal diseaseChronic kidney diseaseCourse of diseaseRenal diseaseKidney diseaseIntensive treatmentAdvance carePatient valuesCognitive declinePatientsSignificant mortalityClinical literatureDecision-making capacityDaily practiceDiseaseYears of supportPhysiciansConvincing evidenceMore trainingMorbidityHospitalClinicMortality
2017
Blood pressure targets for hemodialysis patients
Turner JM, Peixoto AJ. Blood pressure targets for hemodialysis patients. Kidney International 2017, 92: 816-823. PMID: 28938954, DOI: 10.1016/j.kint.2017.01.038.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDialysis unit blood pressureHemodialysis patientsBlood pressureBP targetsBlood pressure targetsLarge observational studiesBenefit-risk balanceBP reductionPressure targetsBP managementTreatment strategiesObservational studyCurrent evidenceDialysis providersGeneral populationClinical practicePatientsHypertensionNephrologistsPopulationTargetMortalityTrials
2016
We Avoid RAAS Inhibitors in PD Patients with Residual Renal Function
Turner JM. We Avoid RAAS Inhibitors in PD Patients with Residual Renal Function. Seminars In Dialysis 2016, 29: 265-267. PMID: 27061273, DOI: 10.1111/sdi.12488.Commentaries, Editorials and LettersConceptsResidual renal functionPeritoneal dialysisRAAS inhibitorsRenal functionAngiotensin receptor blockersGlomerular filtration rateRAAS blockadeAldosterone systemReceptor blockersNephrotoxic agentsPD patientsPD populationFiltration rateModality failureUltrafiltration failureEnzyme inhibitorsPatientsPeritoneal membraneMorphologic changesInhibitorsMortalityCliniciansAnuriaAngiotensinFailure