2012
A Test for Selection Employing Quantitative Trait Locus and Mutation Accumulation Data
Rice DP, Townsend JP. A Test for Selection Employing Quantitative Trait Locus and Mutation Accumulation Data. Genetics 2012, 190: 1533-1545. PMID: 22298701, PMCID: PMC3316662, DOI: 10.1534/genetics.111.137075.Peer-Reviewed Original ResearchConceptsMutation accumulation dataPhenotypic traitsMutational effectsMutation accumulation experimentsPopulation genetics theoryQuantitative trait lociQuantitative phenotypic traitsAccumulation dataHistory of selectionLocus effect sizesEvolutionary biologistsNeutral evolutionGenetic architectureQTL dataStrong selectionTrait lociSelection strengthDistribution of mutationsNatural selectionPhenotypic diversityHistorical selectionMolecular dataQuantitative traitsGenetic theoryQTL
2011
Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures
Johnsen P, Townsend J, Bøhn T, Simonsen G, Sundsfjord A, Nielsen K. Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures. Journal Of Antimicrobial Chemotherapy 2011, 66: 608-610. PMID: 21217128, PMCID: PMC3037156, DOI: 10.1093/jac/dkq512.Peer-Reviewed Original ResearchConceptsPopulation genetic modelsRelative fitness differencesStrong selectionBacterial fitnessFitness differencesFitness costsSelection coefficientsSelective pressureGlycopeptide-resistant Enterococcus faeciumResistance determinantsBiological fitness costBiological costGenetic modelsFarm environmentGlycopeptide resistance