2022
Placing human gene families into their evolutionary context
Dornburg A, Mallik R, Wang Z, Bernal M, Thompson B, Bruford E, Nebert D, Vasiliou V, Yohe L, Yoder J, Townsend J. Placing human gene families into their evolutionary context. Human Genomics 2022, 16: 56. PMID: 36369063, PMCID: PMC9652883, DOI: 10.1186/s40246-022-00429-5.Peer-Reviewed Original ResearchConceptsHuman gene familyGene familyHuman genomeEvolutionary contextGene family evolutionNon-model organismsFirst human genomeGenome biologyComparative genomicsFamily evolutionDistant speciesDraft sequenceGenomic studiesGene expressionGenome sequencingSequence complexityGenomeCancer biologyUnprecedented insightsNovel discoveriesCritical roleOrganismsBiologyComparative approachFamily
2015
Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola
Sistrom M, Park D, O’Brien H, Wang Z, Guttman DS, Townsend JP, Turner PE. Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola. PLOS ONE 2015, 10: e0144514. PMID: 26670219, PMCID: PMC4687649, DOI: 10.1371/journal.pone.0144514.Peer-Reviewed Original ResearchConceptsGene OntologyGene expression variationType IV pilus expressionGene expression comparisonsType IV piliTricarboxylic acid cycle (TCA) cycleType IV pilusNon-piliated strainsPseudomonas syringae pathovar phaseolicolaAcetyl-CoA metabolismEvolutionary biologyTCA pathwayExpression analysisPilus retractionPilus mutantsExpression variationExpression patternsWild typeAerobic respirationGenome sequencingSignificant bacterial pathogensPilus expressionDifferential expressionBacterial cellsPathovar phaseolicola