2023
Updates in Cardiorenal Syndrome
McCallum W, Testani J. Updates in Cardiorenal Syndrome. Medical Clinics Of North America 2023, 107: 763-780. PMID: 37258013, PMCID: PMC10756136, DOI: 10.1016/j.mcna.2023.03.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial
Eder M, Griffin M, Moreno-Villagomez J, Bellumkonda L, Maulion C, Asher J, Wilson F, Cox Z, Ivey-Miranda J, Rao V, Butler J, Borlaug B, McCallum W, Ramos-Mastache D, Testani J. The importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial. International Journal Of Cardiology 2023, 381: 57-61. PMID: 37023862, DOI: 10.1016/j.ijcard.2023.04.002.Peer-Reviewed Original ResearchConceptsRight atrial pressureDiuretic efficiencyRight atrial areaDiuretic responseVenous congestionHeart failureCardio-renal interactionsLoop diuretic doseAcute heart failureRenal perfusion pressureLow cardiac outputMean arterial pressureRight ventricular systolicCongestive heart failureVentricular ejection fractionNet fluid outputForward flowDiuretic doseDiuretic resistanceTTE parametersCardiac indexVentricular systolicArterial pressureAtrial pressureEjection fraction
2016
Renal dysfunction and chronic mechanical circulatory support
Brisco MA, Testani JM, Cook JL. Renal dysfunction and chronic mechanical circulatory support. Current Opinion In Cardiology 2016, 31: 277-286. PMID: 27022890, PMCID: PMC6176489, DOI: 10.1097/hco.0000000000000278.Peer-Reviewed Original ResearchConceptsMechanical circulatory supportRenal dysfunctionRenal functionCirculatory supportChronic mechanical circulatory supportPostoperative acute kidney injuryIrreversible renal dysfunctionAcute kidney injuryRight ventricular dysfunctionAdvanced heart failureCardiogenic shockKidney injuryNeurohormonal activationVentricular dysfunctionMost patientsHeart failureKidney functionSubsequent recurrenceVolume overloadVenous congestionEarly improvementDysfunctionDevice-related effectsReversible formDiagnostic tests
2015
Blood urea nitrogen to creatinine ratio is associated with congestion and mortality in heart failure patients with renal dysfunction
Parrinello G, Torres D, Testani JM, Almasio PL, Bellanca M, Pizzo G, Cuttitta F, Pinto A, Butler J, Paterna S. Blood urea nitrogen to creatinine ratio is associated with congestion and mortality in heart failure patients with renal dysfunction. Internal And Emergency Medicine 2015, 10: 965-972. PMID: 26037394, DOI: 10.1007/s11739-015-1261-1.Peer-Reviewed Original ResearchConceptsBUN/CrInferior vena cavaRenal dysfunctionHeart failureVenous congestionBUN/Cr ratioMultiple logistic regression modelNYHA class 3Independent risk factorLong-term mortalityHeart failure patientsGlomerular filtration rateBlood urea nitrogenReceiver-operating characteristic analysisLogistic regression modelsCause deathHF outpatientsHF severityLower eGFRRenal functionAmbulatory visitsFailure patientsCreatinine ratioSingle centerRenal biomarkersThe kidney in heart failure: an update
Damman K, Testani JM. The kidney in heart failure: an update. European Heart Journal 2015, 36: 1437-1444. PMID: 25838436, PMCID: PMC4465636, DOI: 10.1093/eurheartj/ehv010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHeart failureRenal functionPhenotypes of HFReduced renal perfusionCardiorenal interactionsCardiorenal syndromeHF patientsHF statusRenal dysfunctionRenal perfusionGrim prognosisVenous congestionClinical syndromeTreatment strategiesHigh mortalityPatientsRecent evidenceSyndromeKidneyMortalityUpdated classificationMorbidityFailurePrognosisDysfunction
2014
A Combined-Biomarker Approach to Clinical Phenotyping Renal Dysfunction in Heart Failure
Testani JM, Damman K, Brisco MA, Chen S, Laur O, Kula AJ, Tang WH, Parikh C. A Combined-Biomarker Approach to Clinical Phenotyping Renal Dysfunction in Heart Failure. Journal Of Cardiac Failure 2014, 20: 912-919. PMID: 25152498, PMCID: PMC4292792, DOI: 10.1016/j.cardfail.2014.08.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkersBlood Urea NitrogenCardio-Renal SyndromeCohort StudiesConfidence IntervalsCreatinineFemaleGlomerular Filtration RateHeart FailureHospitals, UniversityHumansMaleMiddle AgedPhenotypePrognosisRenal InsufficiencyRetrospective StudiesSensitivity and SpecificityStatistics, NonparametricSurvival RateConceptsB-type natriuretic peptideElevated B-type natriuretic peptideRenal dysfunctionHeart failureLower B-type natriuretic peptideUse of BNPCombined biomarker approachDecompensated heart failureIntrinsic kidney diseaseBlood urea nitrogenDifferent clinical phenotypesBUN/Diuretic resistanceInotrope useWorse survivalCreatinine ratioRisk stratificationDischarge diagnosisNatriuretic peptideVenous congestionKidney diseaseStratify patientsClinical phenotypingPatientsUrea nitrogen
2010
Effect of Right Ventricular Function and Venous Congestion on Cardiorenal Interactions During the Treatment of Decompensated Heart Failure
Testani JM, Khera AV, St. John Sutton MG, Keane MG, Wiegers SE, Shannon RP, Kirkpatrick JN. Effect of Right Ventricular Function and Venous Congestion on Cardiorenal Interactions During the Treatment of Decompensated Heart Failure. The American Journal Of Cardiology 2010, 105: 511-516. PMID: 20152246, PMCID: PMC2995805, DOI: 10.1016/j.amjcard.2009.10.020.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCardiac Output, LowCohort StudiesCreatinineDiureticsFemaleGlomerular Filtration RateHeart FailureHospitals, UniversityHumansHyperemiaIncidenceKidney DiseasesKidney Function TestsLength of StayMaleMiddle AgedNatriuretic Peptide, BrainPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexUltrasonographyVentricular Dysfunction, RightConceptsSignificant RV dysfunctionDecompensated heart failureRV dysfunctionRenal functionGlomerular filtration rateVenous congestionCardiac outputHeart failureFiltration rateAcute decompensated heart failureMultiple echocardiographic methodsRight ventricular dysfunctionWorsening Renal FunctionRight ventricular functionCardiorenal interactionsRenal outcomesVentricular dysfunctionRV dilationRV functionVentricular functionDischarge diagnosisConsecutive admissionsEchocardiographic methodsLower incidenceHigh incidence