2004
Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature
Sadeghi MM, Schechner JS, Krassilnikova S, Gharaei AA, Zhang J, Kirkiles-Smith N, Sinusas AJ, Zaret BL, Bender JR. Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature. Transplantation Proceedings 2004, 36: 1585-1591. PMID: 15251390, DOI: 10.1016/j.transproceed.2004.05.060.Peer-Reviewed Original ResearchConceptsChimeric human/mouse modelHuman/mouse modelHuman skin graftsEndothelial activationSkin graftsEndothelial cellsMouse modelIsotype-matched control antibodySCID/beige miceTumor necrosis factorEndothelial adhesion moleculesMurine VCAM-1Murine red blood cellsRed blood cellsHuman endothelial cellsControl antibodyInflammatory responseNecrosis factorBeige miceTc-99mVCAM-1Tissue vascularityMonoclonal antibodiesBlood cellsAdhesion molecules
2000
Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein
Sadeghi M, Collinge M, Pardi R, Bender J. Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein. The Journal Of Immunology 2000, 165: 2712-2718. PMID: 10946302, DOI: 10.4049/jimmunol.165.5.2712.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicBiological TransportCell Adhesion MoleculesCells, CulturedCholesterolCytokinesDrug SynergismE-SelectinEndothelium, VascularGene Expression RegulationGTP-Binding Protein alpha Subunits, Gi-GoHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIntercellular Adhesion Molecule-1Interleukin-1NF-kappa BRNA, MessengerSignal TransductionSimvastatinSodium FluorideUmbilical VeinsVascular Cell Adhesion Molecule-1ConceptsEffect of simvastatinCytokine-induced expressionIL-1Endothelial CAMsEndothelial cell adhesion molecules E-selectinNF-kappaBProinflammatory cytokines IL-1Cell adhesion molecules E-selectinAdhesion molecules E-selectinPotent immune modulatorG protein activator NaFCytokines IL-1G protein-coupled pathwayInhibitory G proteinCytokine-mediated activationSelectin mRNA levelsBasal toneProinflammatory cytokinesGialpha proteinsImmune modulatorsTNF-alphaICAM-1Pertussis toxinE-selectinEndothelial response
1998
Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development.
Cuff C, Schwartz J, Bergman C, Russell K, Bender J, Ruddle N. Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development. The Journal Of Immunology 1998, 161: 6853-60. PMID: 9862717, DOI: 10.4049/jimmunol.161.12.6853.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesChemokine CCL2Chemokine CCL4Chemokine CCL5Chemokine CXCL10Chemokine CXCL2ChemokinesChemokines, CXCCytotoxicity, ImmunologicE-SelectinEmbryonic and Fetal DevelopmentGene Expression RegulationHumansImmunoglobulinsInflammationIntercellular Adhesion Molecule-1Lymphoid TissueLymphotoxin-alphaMacrophage Inflammatory ProteinsMiceMonokinesMucoproteinsRecombinant Fusion ProteinsSpecies SpecificityStimulation, ChemicalTumor Cells, CulturedVascular Cell Adhesion Molecule-1ConceptsLymphoid organ developmentMAdCAM-1LT-alphaLT alpha3Adhesion moleculesTreatment periodIFN-inducible protein-10Biologic activityInduction of chemokinesChemotactic protein-1Peripheral node addressinCellular adhesion moleculesMucosal addressin MAdCAM-1Unique biologic activityInflammatory mediatorsChemokine expressionProinflammatory effectsLymphoid tissueMTNF-alphaMaximal killingChemokine RANTESE-selectinKnockout miceProtein 10Alpha preparationsRetroviral Gene Transfer: Effects on Endothelial Cell Phenotype
Inaba M, Toninelli E, Vanmeter G, Bender J, Conte M. Retroviral Gene Transfer: Effects on Endothelial Cell Phenotype. Journal Of Surgical Research 1998, 78: 31-36. PMID: 9733614, DOI: 10.1006/jsre.1998.5379.Peer-Reviewed Original ResearchConceptsEndothelial cellsTransduced ECsCell adhesion molecule profilesCell phenotypeHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsAdhesion molecule profileUpregulation of expressionGT protocolVein endothelial cellsTarget cell phenotypeViral exposureMHC-IICardiovascular diseaseActivation moleculeICAM-1Endothelial cell phenotypeVCAM-1E-selectinGene transferVivo gene transferCell countSystemic deliveryCytokine stimulationUnaltered pattern
1994
To harness the revolution in vascular biology
Bender J. To harness the revolution in vascular biology. Journal Of Nuclear Cardiology 1994, 1: 307-310. PMID: 9420714, DOI: 10.1007/bf02940345.Peer-Reviewed Original Research
1993
Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture.
Petzelbauer P, Bender JR, Wilson J, Pober JS. Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. The Journal Of Immunology 1993, 151: 5062-72. PMID: 7691964, DOI: 10.4049/jimmunol.151.9.5062.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCD36 AntigensCell Adhesion MoleculesCells, CulturedCytokinesDermatitisE-SelectinEndothelium, VascularHumansMiceOrgan Culture TechniquesSkinVascular Cell Adhesion Molecule-1ConceptsVCAM-1 expressionDermal microvascular endothelial cellsSuperficial vascular plexusAdhesion molecule-1 expressionDeep vascular plexusMolecule-1 expressionIL-1IL-4Molecule expressionVascular bedAntigen expressionCD36 expressionEndothelial leukocyte adhesion molecule-1 expressionELAM-1Normal skinEndothelial cell antigen expressionCytokine responsivenessVascular cell adhesion molecule-1 expressionVascular plexusCapillary loopsCell adhesion molecule-1 expressionParticular vascular bedEndothelial leukocyte adhesion moleculeAdhesion molecule expressionSites of inflammation