2010
T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade
Ramgolam VS, DeGregorio SD, Rao GK, Collinge M, Subaran SS, Markovic-Plese S, Pardi R, Bender JR. T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade. PLOS ONE 2010, 5: e14450. PMID: 21206905, PMCID: PMC3012057, DOI: 10.1371/journal.pone.0014450.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceCytokinesELAV ProteinsELAV-Like Protein 1GTP PhosphohydrolasesHumansIntegrinsInterferon-gammaLymphocyte Function-Associated Antigen-1MAP Kinase Kinase 3MiceMice, Inbred C57BLNeuropeptidesP38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins c-vavRac GTP-Binding ProteinsRac1 GTP-Binding ProteinRNA-Binding ProteinsSignal TransductionT-LymphocytesTumor Necrosis Factor-alpha
2006
Pathophysiology of leukocyte–tissue interactions
Molteni R, Fabbri M, Bender JR, Pardi R. Pathophysiology of leukocyte–tissue interactions. Current Opinion In Cell Biology 2006, 18: 491-498. PMID: 16904306, DOI: 10.1016/j.ceb.2006.08.001.Peer-Reviewed Original Research
2002
Integrin‐dependent regulation of gene expression in leukocytes
Rossetti G, Collinge M, Molteni R, Bender J, Pardi R. Integrin‐dependent regulation of gene expression in leukocytes. Immunological Reviews 2002, 186: 189-207. PMID: 12234372, DOI: 10.1034/j.1600-065x.2002.18616.x.Peer-Reviewed Original ResearchConceptsIntegrin engagementGene expression regulationIntegrin-dependent regulationCell cycle restriction pointExpression regulationNumerous genesTransduce signalsMatrix degrading proteinsTranscriptional activationGenetic programTranscription modulatorsIntegrin-dependent mechanismJAK-STATsGene expressionIntercellular adhesionDegrading proteinsCell differentiationAlphaLbeta2 integrinJab-1Restriction pointMRNA transcriptsT cell differentiationEnvironmental stimuliPotent signalCell phenotype
1998
Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement
Wang G, Collinge M, Blasi F, Pardi R, Bender J. Posttranscriptional regulation of urokinase plasminogen activator receptor messenger RNA levels by leukocyte integrin engagement. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6296-6301. PMID: 9600959, PMCID: PMC27663, DOI: 10.1073/pnas.95.11.6296.Peer-Reviewed Original ResearchConceptsAU-rich elementsLFA-1 activationMRNA degradationReporter constructsUrokinase plasminogen activator receptorT cell activationCrucial cis-acting elementsCis-acting elementsLymphocyte function-associated antigen-1Integrin lymphocyte function-associated antigen-1Jurkat T cellsLFA-1 engagementUPAR cDNAReceptor-mediated signalingPosttranscriptional regulationTransmembrane signalingReporter mRNAIntegrin engagementCell activationInhibitor 5Adhesion receptorsSecond messengerMessenger RNA levelsPlasminogen activator receptorFunction-associated antigen-1
1995
Lymphocyte adhesion-dependent calcium signaling in human endothelial cells.
Pfau S, Leitenberg D, Rinder H, Smith BR, Pardi R, Bender JR. Lymphocyte adhesion-dependent calcium signaling in human endothelial cells. Journal Of Cell Biology 1995, 128: 969-978. PMID: 7533170, PMCID: PMC2120392, DOI: 10.1083/jcb.128.5.969.Peer-Reviewed Original ResearchConceptsEC Ca2Endothelial cellsEC alterationsLymphocyte-endothelial interactionsNatural killer cellsImmune effector cellsTumor necrosis factorHuman umbilical vein endothelial cellsCytosolic free calcium changesUmbilical vein endothelial cellsVascular endothelial cellsHuman umbilical vein ECsAllogeneic CD3Lymphocyte subsetsVein endothelial cellsHuman endothelial cellsNK cellsEffector cellsKiller cellsVascular toneInflammatory responseNecrosis factorSecond messenger pathwaysExtracellular influxCytokine activation