2007
Variant estrogen receptor–c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation
Li L, Hisamoto K, Kim KH, Haynes MP, Bauer PM, Sanjay A, Collinge M, Baron R, Sessa WC, Bender JR. Variant estrogen receptor–c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 16468-16473. PMID: 17921256, PMCID: PMC2034248, DOI: 10.1073/pnas.0704315104.Peer-Reviewed Original ResearchConceptsC-SrcC-Src kinase activityTyrosine kinase c-SrcRapid signal transductionKinase c-SrcC-Src functionC-Src kinaseEndothelial NO synthase activationENOS activationMembrane recruitmentSignal transductionComplex assemblyPlasma membraneKinase activityOestrogen receptor-alpha variantsVenous endothelial cellsER46Pathway activationHormonal stimuliCritical roleArterial responseNO synthase activationSynthase activationStructural requirementsEndothelial cells
2002
Endothelial cell seeding influences lesion development following arterial injury in the cholesterol-fed rabbit
Conte MS, VanMeter GA, Akst LM, Clemons T, Kashgarian M, Bender JR. Endothelial cell seeding influences lesion development following arterial injury in the cholesterol-fed rabbit. Cardiovascular Research 2002, 53: 502-511. PMID: 11827702, DOI: 10.1016/s0008-6363(01)00486-2.Peer-Reviewed Original ResearchConceptsFinal lumen areaEndothelial cellsEndothelial restorationNeointimal areaLumen areaAutologous venous endothelial cellsLarger neointimal areaPositive remodeling indexBalloon catheter injuryTime of injuryHigh-grade stenosisCholesterol-fed rabbitsCholesterol-supplemented dietVessel wall repairVenous endothelial cellsIntact endothelial monolayerCatheter injuryRemodeling indexArterial injuryBalloon angioplastyIliofemoral arteriesContralateral vesselLuminal diameterVascular remodelingGrade stenosis