Cytokines and cardiovascular disease
Mehra VC, Ramgolam VS, Bender JR. Cytokines and cardiovascular disease. Journal Of Leukocyte Biology 2005, 78: 805-818. PMID: 16006537, DOI: 10.1189/jlb.0405182.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseMyocardial functionNitric oxideMyocardial depressant effectsProgression of atherosclerosisRole of cytokinesRelease of cytokinesArachidonic acid metabolitesInflammatory mechanismsHeart failureInflammatory cascadeDepressant effectCytokine influenceImmune cascadeAcid metabolitesCytokinesBiochemical effectsDiseaseCommon formAtherosclerosisChemokinesReviewPathogenesisProgressionComprehensive reviewRapid, Estrogen Receptor–Mediated Signaling: Why Is the Endothelium So Special?
Kim KH, Bender JR. Rapid, Estrogen Receptor–Mediated Signaling: Why Is the Endothelium So Special? Science Signaling 2005, 2005: pe28. PMID: 15956360, DOI: 10.1126/stke.2882005pe28.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsCaveolaeCoronary DiseaseEndothelium, VascularEnzyme ActivationEstrogen Replacement TherapyFemaleHumansMaleMiddle AgedNitric OxideNitric Oxide Synthase Type IIIPostmenopausePremenopauseProtein IsoformsProto-Oncogene Proteins pp60(c-src)Randomized Controlled Trials as TopicReceptors, EstrogenSex DistributionSignal TransductionConceptsEstrogen receptorEndothelial NO synthaseNitric oxideEndothelial cellsHormone replacement therapyMembrane estrogen receptorsEndothelial activationVascular healthReplacement therapyCardiovascular diseaseVascular pathologyNO synthasePotent stimulusEstrogen responseFunctional alterationsENOS activationNongenomic responsesNO releaseRegulatory tissuesGenomic effectsCommon formProtective substancesMajor targetEndotheliumReceptors