1999
The role of voltage-gated Ca2+ channels in anoxic injury of spinal cord white matter
Imaizumi T, Kocsis J, Waxman S. The role of voltage-gated Ca2+ channels in anoxic injury of spinal cord white matter. Brain Research 1999, 817: 84-92. PMID: 9889329, DOI: 10.1016/s0006-8993(98)01214-1.Peer-Reviewed Original ResearchConceptsVoltage-gated Ca2Spinal cord axonsAnoxic injuryDorsal columnsR-type voltage-gated Ca2N-type calcium channelsSpinal cord white matterRat dorsal columnsDorsal column axonsR-type Ca2Rat spinal cordCord white matterT-type channelsInflux of Ca2Dose-dependent mannerLoss of conductionAxonal conductionSpinal cordChannel blockersCalcium channelsSurface stimulationWhite matterPerfusion solutionInjuryGlass microelectrodes
1998
Morphologically Identified Cutaneous Afferent DRG Neurons Express Three Different Potassium Currents in Varying Proportions
Everill B, Rizzo M, Kocsis J. Morphologically Identified Cutaneous Afferent DRG Neurons Express Three Different Potassium Currents in Varying Proportions. Journal Of Neurophysiology 1998, 79: 1814-1824. PMID: 9535950, PMCID: PMC2605378, DOI: 10.1152/jn.1998.79.4.1814.Peer-Reviewed Original ResearchConceptsDRG neuronsMedium-sized DRG neuronsDorsal root ganglion neuronsCutaneous afferent neuronsDifferent potassium currentsWhole-cell patch-clamp configurationOutward current componentPatch-clamp configurationAfferent neuronsFluoro-GoldGanglion neuronsRetrograde labelingConditioning prepulseEntire populationChannel blockersPotassium currentMyelinated axonsSustained currentNeuronsTest pulseDendrotoxinBasis of sensitivityIKCellsBlockersVigabatrin enhances promoted release of GABA in neonatal rat optic nerve
Yee J, Agulian S, Kocsis J. Vigabatrin enhances promoted release of GABA in neonatal rat optic nerve. Epilepsy Research 1998, 29: 195-200. PMID: 9551781, DOI: 10.1016/s0920-1211(97)00086-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnticonvulsantsAstrocytesAxonsBicucullineCarrier ProteinsGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidIn Vitro TechniquesMembrane PotentialsMembrane ProteinsMembrane Transport ProteinsModels, NeurologicalNipecotic AcidsOptic NerveOrganic Anion TransportersPotassium ChlorideProlineRatsRats, WistarReceptors, GABA-ATime FactorsVigabatrinConceptsRelease of GABAGABA levelsNipecotic acidNeonatal rat optic nerveGABA transporter inhibitorOptic nerve axonsRat optic nerveOptic nerve astrocytesEnzyme GABA transaminaseGABA transaminase activityFree GABA levelsOptic nerveAntiepileptic drugsNO-711GABA transporterNerve axonsTransaminase activityGABA transaminaseVigabatrinTransporter inhibitorsGABADepolarizationGreater releaseElevationRelease
1996
Mechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na+ Channel Heterogeneity
Rizzo M, Kocsis J, Waxman S. Mechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na+ Channel Heterogeneity. European Neurology 1996, 36: 3-12. PMID: 8719643, DOI: 10.1159/000117192.Peer-Reviewed Original ResearchConceptsAxonal injuryCutaneous afferentsDorsal root ganglion neuronsAction potential activityNormal sensory functionEctopic impulsesDRG neuronsClinical syndromeGanglion neuronsSensory functionMembrane excitabilityInjuryNerve impulsesDysesthesiaeChannel physiologyMolecular changesParesthesiaeAfferentsPreliminary evidenceNeuronsEctopicMolecular mechanismsSensory anatomyPotential activityPopulation
1995
The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis
Honmou O, Oyelese A, Kocsis J. The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis. Brain Research 1995, 692: 273-277. PMID: 8548315, DOI: 10.1016/0006-8993(95)00634-3.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsFree GABA levelsField potential analysisNipecotic acidGABA levelsPopulation excitatory postsynaptic potentialEffects of microapplicationRelease of GABAGABAA receptor activationAdult rat brainMechanism of actionGABA releasePartial seizuresAnticonvulsant gabapentinPresynaptic volleyPostsynaptic potentialsBath applicationHippocampal slicesRat brainGBP treatmentHippocampal cellsBlock uptakeGabapentinReceptor activationGABAEnhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons
Oyelese A, Eng D, Richerson G, Kocsis J. Enhancement of GABAA receptor-mediated conductances induced by nerve injury in a subclass of sensory neurons. Journal Of Neurophysiology 1995, 74: 673-683. PMID: 7472373, PMCID: PMC2605359, DOI: 10.1152/jn.1995.74.2.673.Peer-Reviewed Original ResearchConceptsDRG neuronsAction potential durationMedium neuronsNerve injurySmall neuronsLarge neuronsAction potentialsGABA conductanceNerve ligationControl neuronsPotential durationAdult rat dorsal root ganglion neuronsGABAA receptor-mediated conductanceRat dorsal root ganglion neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion neuronsMean action potential durationShort-duration action potentialsControl DRG neuronsSciatic nerve ligationEffects of axotomyReceptor-mediated conductanceTraumatic nerve injuryPatch-clamp recordingsGabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro
Honmou O, Kocsis J, Richerson G. Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro. Epilepsy Research 1995, 20: 193-202. PMID: 7796791, DOI: 10.1016/0920-1211(94)00076-9.Peer-Reviewed Original ResearchConceptsRelease of GABACA1 pyramidal neuronsNipecotic acidPyramidal neuronsGABAA receptorsWhole-cell patch-clamp recordingsGABA uptake systemRat optic nerveCalcium-free solutionPeriod of hyperexcitabilityPatch-clamp recordingsChloride equilibrium potentialMechanism of actionGabapentin exposurePartial seizuresPressure microejectionOptic nerveAnticonvulsant gabapentinNonvesicular releaseHippocampal slicesNeuronal inhibitionMetabolic effectsSynaptic transmissionWhole-cell conductanceClamp recordings
1994
Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve
Kocsis J, Honmou O. Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve. Neuroscience Letters 1994, 169: 181-184. PMID: 8047279, DOI: 10.1016/0304-3940(94)90386-7.Peer-Reviewed Original ResearchRetinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors
Ahmad I, Leinders-Zufall T, Kocsis J, Shepherd G, Zufall F, Barnstable C. Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron 1994, 12: 155-165. PMID: 7507337, DOI: 10.1016/0896-6273(94)90160-0.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsAnimals, NewbornBase SequenceCells, CulturedCyclic GMPCyclic Nucleotide-Gated Cation ChannelsCysteineDNA PrimersElectric ConductivityGene ExpressionIn Situ HybridizationIon ChannelsMembrane PotentialsModels, NeurologicalMolecular Sequence DataNitric OxideNitroprussidePolymerase Chain ReactionRatsRats, WistarRetinal Ganglion CellsRetinal Rod Photoreceptor CellsS-NitrosothiolsTranscription, GeneticConceptsRetinal ganglion cellsGanglion cellsWhole-cell patch-clamp recordingsRat retinal ganglion cellsNitric oxide donor sodium nitroprussideCation channelsGanglion cell activityPatch-clamp recordingsCation conductanceNitric oxide donorDonor sodium nitroprussideNonselective cation channelsAmacrine cellsSodium nitroprussideOxide donorPhosphodiesterase inhibitorCell activityPolymerase chain reaction amplificationNitric oxideChain reaction amplificationReversal potentialOutward rectificationRod photoreceptorsCGMPS-nitrosocysteine
1992
Mutual excitation among dorsal root ganglion neurons in the rat
Utzschneider D, Kocsis J, Devor M. Mutual excitation among dorsal root ganglion neurons in the rat. Neuroscience Letters 1992, 146: 53-56. PMID: 1475049, DOI: 10.1016/0304-3940(92)90170-c.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGanglia, SpinalIn Vitro TechniquesKineticsMembrane PotentialsMicroelectrodesMyelin SheathNeuronsPotassiumRatsRats, WistarConceptsDorsal root gangliaDorsal rootsDorsal root ganglion neuronsPrimary sensory neuronsExcised dorsal root gangliaNerve injuryDRG neuronsGanglion neuronsMost neuronsRoot gangliaSensory abnormalitiesIntracellular recordingsDR stimulationRepetitive stimulationSensory neuronsTransient riseNeighboring neuronsNeuronsStimulationSimilar kineticsMutual excitationGangliaInjuryRatsAbnormalitiesIntranuclear Ca2+ transients during neurite regeneration of an adult mammalian neuron.
Birch B, Eng D, Kocsis J. Intranuclear Ca2+ transients during neurite regeneration of an adult mammalian neuron. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 7978-7982. PMID: 1518824, PMCID: PMC49838, DOI: 10.1073/pnas.89.17.7978.Peer-Reviewed Original ResearchConceptsNeurite extensionNuclear eventsMammalian dorsal root ganglion neuronsSubcellular calcium transientsIntranuclear Ca2Confocal laser scanning microscopyGene expressionMammalian neuronsAdult mammalian neuronsCytoplasmic levelsLaser scanning microscopyNuclear Ca2Importance of Ca2Activity-dependent modulationScanning microscopyNeurite regenerationDepolarization-induced increaseCa2Transmembrane Ca2Dorsal root ganglion neuronsRegenerationExtracellular Ca2CytoplasmNucleusNeuronsConduction properties of spinal cord axons in the myelin-deficient rat mutant
Utzschneider D, Black J, Kocsis J. Conduction properties of spinal cord axons in the myelin-deficient rat mutant. Neuroscience 1992, 49: 221-228. PMID: 1407548, DOI: 10.1016/0306-4522(92)90090-o.Peer-Reviewed Original ResearchConceptsDorsal column axonsMyelin-deficient rat mutantsSpinal cordFrequency-dependent conduction blockNormal age-matched ratsBrain slice chamberMyelin-deficient rat spinal cordAction potential dischargeRat mutantAge-matched ratsRat spinal cordSpinal cord axonsAction potential conductionControl ratsDemyelinated axonsConduction blockConduction velocityRefractory periodPotential dischargeControl axonsSlice chamberPharmacological resultsPotential conductionAxonsCompensatory mechanismsTransient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve
Sakatani K, Black J, Kocsis J. Transient presence and functional interaction of endogenous GABA and GABAA receptors in developing rat optic nerve. Proceedings Of The Royal Society B 1992, 247: 155-161. PMID: 1349183, DOI: 10.1098/rspb.1992.0022.Peer-Reviewed Original ResearchConceptsRat optic nerveOptic nerveCentral nervous systemGABAA receptorsIntact rat optic nerveCultured glia cellsFunctional GABAA receptorsGABAA receptor agonistNeonatal optic nerveNeuronal cell bodiesO-2A progenitor cellsNon-synaptic sitesPre-myelinated axonsWhite matter regionsSynthesis of GABAAxonal excitabilityReceptor agonistEndogenous GABAGABA uptakeGlia cellsSynaptic neurotransmittersNervous systemEndogenous neurotransmittersType 2Nerve
1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1989
Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve
Gordon T, Kocsis J, Waxman S. Pharmacological sensitivities of two afterhyperpolarizations in rat optic nerve. Brain Research 1989, 502: 252-257. PMID: 2555026, DOI: 10.1016/0006-8993(89)90620-3.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsFemaleMembrane PotentialsNeural InhibitionOptic NerveRatsRats, Inbred StrainsTetraethylammonium CompoundsConceptsRat optic nerveOptic nerveEarly afterhyperpolarizationPharmacological sensitivityAction potentialsPeak latencyAction potential broadeningConstant current depolarizationSucrose gap chamberPotassium channel blockerLate afterhyperpolarizationChannel blockersRepetitive stimulationAfterhyperpolarizationNervePotassium conductanceSucrose gapTetraethylammoniumPotential broadeningCurrent depolarizationDepolarizationDurationApaminBlockersCharybdotoxin
1984
Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in rat cerebellar cortex.
Kocsis J, Eng D, Bhisitkul R. Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in rat cerebellar cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6531-6534. PMID: 6093104, PMCID: PMC391958, DOI: 10.1073/pnas.81.20.6531.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSynaptic activityCerebellar cortexAction of adenosineEfficacy of adenosineRat cerebellar cortexClimbing fiber inputParallel fibersAdenosine applicationSynaptic potentialsSynaptic transmissionFiber activityPurkinje cellsAxon excitabilityElectrophysiological techniquesExcitability propertiesDendritic membraneCortexAdenosineConvergent parallelSelective blockingDirect alterationExcitability
1983
Effects of extracellular potassium concentration on the excitability of the parallel fibres of the rat cerebellum.
Kocsis J, Malenka R, Waxman S. Effects of extracellular potassium concentration on the excitability of the parallel fibres of the rat cerebellum. The Journal Of Physiology 1983, 334: 225-244. PMID: 6864558, PMCID: PMC1197311, DOI: 10.1113/jphysiol.1983.sp014491.Peer-Reviewed Original Research
1982
Effects of GABA on stimulus-evoked changes in [K+]o and parallel fiber excitability.
Malenka R, Kocsis J. Effects of GABA on stimulus-evoked changes in [K+]o and parallel fiber excitability. Journal Of Neurophysiology 1982, 48: 608-621. PMID: 6290614, DOI: 10.1152/jn.1982.48.3.608.Peer-Reviewed Original ResearchIntra-axonal recordings in rat dorsal column axons: membrane hyperpolarization and decreased excitability precede the primary afferent depolarization
Kocsis J, Waxman S. Intra-axonal recordings in rat dorsal column axons: membrane hyperpolarization and decreased excitability precede the primary afferent depolarization. Brain Research 1982, 238: 222-227. PMID: 6282392, DOI: 10.1016/0006-8993(82)90787-9.Peer-Reviewed Original ResearchConceptsPrimary afferent depolarizationIntra-axonal recordingsRat lumbosacral spinal cordDorsal column stimulationDorsal root potentialsLumbosacral spinal cordDorsal column axonsDorsal columnsDorsal rootsAxonal depolarizationRoot potentialsSpinal cordGABA responsesNeuronal elementsIntracellular correlatesProlonged depolarizationMembrane hyperpolarizationHyperpolarizationDepolarizationExcitability
1981
Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium
Malenka R, Kocsis J, Ransom B, Waxman S. Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium. Science 1981, 214: 339-341. PMID: 7280695, DOI: 10.1126/science.7280695.Peer-Reviewed Original ResearchConceptsSynaptic field potentialsField potentialsParallel fiber stimulationExtracellular potassium concentrationRat cerebellar cortexParallel fibersAfferent fibersPostsynaptic elementsFiber excitabilityCerebellar cortexExtracellular potassiumFiber stimulationExcitabilityMarked increasePotassium concentrationStimulationMolecular layer