1998
Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion
Lankford K, Waxman S, Kocsis J. Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion. The Journal Of Comparative Neurology 1998, 391: 11-29. PMID: 9527536, PMCID: PMC2605358, DOI: 10.1002/(sici)1096-9861(19980202)391:1<11::aid-cne2>3.0.co;2-u.Peer-Reviewed Original ResearchConceptsDorsal root gangliaConditioning lesionNerve injuryNerve regenerationAffected dorsal root ganglionControl dorsal root gangliaDenervated peripheral nervePrior nerve injurySciatic nerve lesionCultured DRG neuronsSciatic nerve transectionPeripheral target tissuesPeripheral nerve stumpRapid nerve regenerationAbility of neuronsSecond axotomyNerve lesionsDRG neuronsNerve transectionNerve stumpRoot gangliaControl neuronsPeripheral nervesNerve tractsAdult rats
1996
Chapter 5 Cellular mechanisms regulating neurite initiation
Lankford K, Kenney A, Kocsis J. Chapter 5 Cellular mechanisms regulating neurite initiation. Progress In Brain Research 1996, 108: 55-81. PMID: 8979794, DOI: 10.1016/s0079-6123(08)62532-7.Peer-Reviewed Original ResearchConceptsNeurite initiationImmediate early genesGrowth cone behaviorEarly genesNeurite formationCell typesCellular mechanismsNeurite outgrowthCellular changesCone behaviorCritical roleMacromolecular levelOutgrowthInitial eventPossible roleMorphological changesProtein 43Complex processMorphogenesisGenesMicrotubulesInitiationProteinCalcium transientsMechanism
1994
Intracellular calcium mobilization and neurite outgrowth in mammalian neurons
Kocsis J, Rand M, Lankford K, Waxman S. Intracellular calcium mobilization and neurite outgrowth in mammalian neurons. Developmental Neurobiology 1994, 25: 252-264. PMID: 8195789, DOI: 10.1002/neu.480250306.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCaffeineCalciumCalcium ChannelsCell CompartmentationCell DifferentiationCells, CulturedFemaleGanglia, SpinalGene Expression RegulationImage Processing, Computer-AssistedIntracellular FluidIon Channel GatingLasersMicroscopy, FluorescenceModels, BiologicalNeuritesNeuronsRatsRats, WistarTerpenesThapsigarginConceptsDepolarization-induced Ca2Calcium-induced calcium releaseDRG neuronsIntracellular Ca2Cultured adult rat dorsal root ganglion neuronsAdult rat dorsal root ganglion neuronsRat dorsal root ganglion neuronsNeurite outgrowthDorsal root ganglion neuronsIntact intracellular Ca2Intracellular calcium mobilizationIndicator dye fluo-3Nuclear Ca2Dye Fluo-3Endoplasmic reticulum Ca2Ganglion neuronsCalcium mobilizationDependent kinase IICalcium releaseFluo-3NeuronsMammalian neuronsReticulum Ca2Elevated Ca2Elicit neurite outgrowthChapter 14 Nuclear calcium elevation may initiate neurite outgrowth in mammalian neurons
Kocsis J, Rand M, Lankford K, Waxman S. Chapter 14 Nuclear calcium elevation may initiate neurite outgrowth in mammalian neurons. Progress In Brain Research 1994, 103: 137-151. PMID: 7886202, DOI: 10.1016/s0079-6123(08)61134-6.Peer-Reviewed Original Research
1992
Intranuclear Ca2+ transients during neurite regeneration of an adult mammalian neuron.
Birch B, Eng D, Kocsis J. Intranuclear Ca2+ transients during neurite regeneration of an adult mammalian neuron. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 7978-7982. PMID: 1518824, PMCID: PMC49838, DOI: 10.1073/pnas.89.17.7978.Peer-Reviewed Original ResearchConceptsNeurite extensionNuclear eventsMammalian dorsal root ganglion neuronsSubcellular calcium transientsIntranuclear Ca2Confocal laser scanning microscopyGene expressionMammalian neuronsAdult mammalian neuronsCytoplasmic levelsLaser scanning microscopyNuclear Ca2Importance of Ca2Activity-dependent modulationScanning microscopyNeurite regenerationDepolarization-induced increaseCa2Transmembrane Ca2Dorsal root ganglion neuronsRegenerationExtracellular Ca2CytoplasmNucleusNeurons