2000
Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord
Imaizumi T, Lankford K, Burton W, Fodor W, Kocsis J. Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord. Nature Biotechnology 2000, 18: 949-953. PMID: 10973214, PMCID: PMC2605371, DOI: 10.1038/79432.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsCD59 AntigensCell SeparationElectrophysiologyFlow CytometryFluorescent Antibody Technique, IndirectHumansImmunosuppression TherapyModels, BiologicalOlfactory NerveRatsRats, WistarRegenerationSchwann CellsSciatic NerveSpinal CordSwineTransgenesTransplantation, HeterologousConceptsAxonal regenerationSpinal cordSchwann cellsImpulse conductionLesion-control ratsDorsal column lesionTransplantation of olfactoryRat spinal cordConduction velocity measurementsComplement inhibitory proteinsHyperacute responseRegenerated axonsImmunosuppressed ratsTransection siteLesion sitePeripheral patternHost tractCordNormal axonsDonor cellsAxonsInhibitory proteinRatsDonor cell typeTransgenic pigsTransplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord
Kato T, Honmou O, Uede T, Hashi K, Kocsis J. Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord. Glia 2000, 30: 209-218. PMID: 10756071, PMCID: PMC2605375, DOI: 10.1002/(sici)1098-1136(200005)30:3<209::aid-glia1>3.0.co;2-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCation Transport ProteinsCell SizeCells, CulturedDemyelinating DiseasesDNA ProbesFemaleFungal ProteinsHumansIn Situ HybridizationMembrane Transport ProteinsMicroscopy, ElectronMiddle AgedMyelin SheathNeurogliaOlfactory NerveRatsRats, WistarSaccharomyces cerevisiae ProteinsSpinal CordConceptsSpinal cordDemyelinated rat spinal cordHuman olfactoryImmunosuppressed adult ratsDemyelinated spinal cordAdult mammalian CNSRat spinal cordExtensive remyelinationHuman OECsDemyelinated axonsOlfactory nervePeripheral typeSchwann cellsAdult ratsLesion siteMammalian CNSMyelin sheathRemyelinationCordAxonsSitu hybridizationSimilar numberOlfactoryCellsLarge nuclei
1986
Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine
Targ E, Kocsis J. Action potential characteristics of demyelinated rat sciatic nerve following application of 4-aminopyridine. Brain Research 1986, 363: 1-9. PMID: 3004637, DOI: 10.1016/0006-8993(86)90652-9.Peer-Reviewed Original ResearchConceptsAction potentialsSciatic nerveFrequency-following abilityMultiple spike dischargesSite of demyelinationCompound action potentialPotassium channel blockerRat sciatic nerveAction potential characteristicsVariety of abnormalitiesAbsolute refractory periodExcitability changesPharmacological blockadeSpontaneous firingDemyelinated axonsChannel blockersConduction slowingConduction blockSpike dischargesLesion siteRefractory periodExcitability propertiesClinical useAxonsPotassium channels