1998
A summary of mechanistic hypotheses of gabapentin pharmacology
Taylor C, Gee N, Su T, Kocsis J, Welty D, Brown J, Dooley D, Boden P, Singh L. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Research 1998, 29: 233-249. PMID: 9551785, DOI: 10.1016/s0920-1211(97)00084-3.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisNon-vesicular GABA releaseCellular mechanismsVoltage-sensitive Ca2Specific amino acid transportersGabapentin bindsGABA releaseNeuronal deathElectrophysiology resultsAnticonvulsant drugsLateral sclerosisNeuroprotective activityNeurobehavioral actionsPharmacological actionsGabapentinAnimal modelsHuman whole bloodBrain tissueMonoamine neurotransmittersAmino acid transportersWhole bloodAcid transportersAuxiliary subunitsPharmacologyRate of synthesis
1996
GABA Levels in the Brain: A Target for New Antiepileptic Drugs
Kocsis J, Mattson R. GABA Levels in the Brain: A Target for New Antiepileptic Drugs. The Neuroscientist 1996, 2: 326-334. DOI: 10.1177/107385849600200610.Peer-Reviewed Original ResearchAntiepileptic drugsGABA levelsBrain GABA systemsBrain GABA levelsSeverity of seizuresNew antiepileptic drugsAbundant inhibitory neurotransmitterGABA receptor sitesNormal electrical activityMinimal side effectsPrecise cellular mechanismsAntiepileptic actionGABA releaseSeizure dischargesGABA systemPharmacological treatmentInhibitory neurotransmitterCNS neuronsEffective antiepilepticSide effectsElectrophysiological studiesMetabolic modulatorsClinical useSodium channelsDrugs
1995
The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis
Honmou O, Oyelese A, Kocsis J. The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis. Brain Research 1995, 692: 273-277. PMID: 8548315, DOI: 10.1016/0006-8993(95)00634-3.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsFree GABA levelsField potential analysisNipecotic acidGABA levelsPopulation excitatory postsynaptic potentialEffects of microapplicationRelease of GABAGABAA receptor activationAdult rat brainMechanism of actionGABA releasePartial seizuresAnticonvulsant gabapentinPresynaptic volleyPostsynaptic potentialsBath applicationHippocampal slicesRat brainGBP treatmentHippocampal cellsBlock uptakeGabapentinReceptor activationGABA