Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents
Kocsis J, Waxman S. Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents. Nature 1983, 304: 640-642. PMID: 6308475, DOI: 10.1038/304640a0.Peer-Reviewed Original ResearchConceptsNerve fibersPotassium channelsMyelinated peripheral nerve fibresAxon segmentsPeripheral nerve fibersAxon sproutsEndoneurial tubesNerve crushFunctional recoveryFunctional organizationMyelinated fibersAxon cylindersSchwann cellsBurst activityMyelinated axonsMammalian axonsAxonsPeripheral connectionsMembrane depolarizationBasement membraneK channelsRegenerated fibersAxon maturationEffects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum
Preston R, Waxman S, Kocsis J. Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum. Experimental Neurology 1983, 79: 808-820. PMID: 6825765, DOI: 10.1016/0014-4886(83)90044-4.Peer-Reviewed Original ResearchConceptsRat corpus callosumCallosal fibersCerebral axonsNerve fibersCorpus callosumMammalian peripheral nerve fibersNegative waveVoltage-dependent potassium currentsSecond negative waveNon-myelinated nerve fibresPeripheral nerve fibersField potentialsShort-latency wavesFirst negative waveCallosal stimulationPotassium blockersPotassium currentAction potentialsPeripheral fibersCallosumRecording electrodesMembrane repolarizationAxonsFunctional organizationComparable differencesELECTROPHYSIOLOGY OF CONDUCTION IN MAMMALIAN REGENERATING NERVES11This work was supported in part by the Veterans Administration and by grants from the National Institutes of Health and the National Multiple Sclerosis Society.
Kocsis J, Waxman S. ELECTROPHYSIOLOGY OF CONDUCTION IN MAMMALIAN REGENERATING NERVES11This work was supported in part by the Veterans Administration and by grants from the National Institutes of Health and the National Multiple Sclerosis Society. 1983, 89-107. DOI: 10.1016/b978-0-12-635120-0.50010-2.Peer-Reviewed Original ResearchMyelinated axonsAction potentialsNational Multiple Sclerosis SocietyMultiple Sclerosis SocietyIntra-axonal recordingsEarly regenerating fibersNormal myelinated axonsRegenerating fibersPharmacological blockageBurst activityPotassium conductanceAxonsVeterans AdministrationNational InstituteRegenerated fibersRepolarizationFunctional organizationIonic channelsRatsAdministrationMyelin