Nascent fusion pore opening monitored at single-SNAREpin resolution
Heo P, Coleman J, Fleury JB, Rothman JE, Pincet F. Nascent fusion pore opening monitored at single-SNAREpin resolution. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2024922118. PMID: 33495324, PMCID: PMC7865171, DOI: 10.1073/pnas.2024922118.Peer-Reviewed Original ResearchConceptsFusion poreFusion pore openingTransient fusion poresSingle fusion eventFast neurotransmitter releaseSingle SNAREpinAsymmetric lipid bilayerProtein complexesSNAREpinsTarget membraneFusion eventsCellular traffickingVesicle fusionSmall vesiclesIon channelsLipid bilayersCargo transportKey eventsEnergy landscapePore openingNeurotransmitter releaseDiscrete sizesVesiclesSynaptic transmissionCargo release