2023
Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression
Jajosky R, Patel K, Allen J, Zerra P, Chonat S, Ayona D, Maier C, Morais D, Wu S, Luckey C, Eisenbarth S, Roback J, Fasano R, Josephson C, Manis J, Chai L, Hendrickson J, Hudson K, Arthur C, Stowell S. Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. Blood 2023, 142: 1082-1098. PMID: 37363865, PMCID: PMC10541552, DOI: 10.1182/blood.2022018591.Peer-Reviewed Original ResearchConceptsAntibody-mediated immunosuppressionRBC alloantigensImmune responseFetal red blood cell antigensTarget antigenRed blood cell antigensRh immune globulinMaternal immune responseBlood cell antigensInclusion of antibodiesRBC removalAnti-RhD antibodiesAbility of antibodiesImmune globulinAntibody responseHemolytic diseaseRBC clearanceCell antigensFetal RBCsAntibody characteristicsAlloantigensSimilar interventionsAntibodiesAntigenPolyclonal antibody preparationStorage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice
Maier C, Jajosky R, Patel S, Verkerke H, Fuller M, Allen J, Zerra P, Fasano R, Chonat S, Josephson C, Gibb D, Eisenbarth S, Luckey C, Hudson K, Hendrickson J, Arthur C, Stowell S. Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice. Transfusion 2023, 63: 457-462. PMID: 36708051, PMCID: PMC10414794, DOI: 10.1111/trf.17251.Peer-Reviewed Original ResearchConceptsKEL RBCsAntibody formationAntigen levelsRed blood cell alloimmunizationIgG antibody productionDifferent clinical outcomesIgG antibody formationRed cell antigensAlloantibody productionRBC alloimmunizationClinical outcomesTransfusionAlloimmunizationRBC clearanceCell antigensClinical experienceSpecific antigenAntibody productionRBC antigensRBC survivalAntibody developmentModel antigenAntigenAdditional studiesFresh RBCsPrior immunization against an intracellular antigen enhances subsequent red blood cell alloimmunization in mice
Jajosky R, Patel S, Wu S, Patel K, Covington M, Vallecillo-Zúniga M, Ayona D, Bennett A, Luckey C, Hudson K, Hendrickson J, Eisenbarth S, Josephson C, Zerra P, Stowell S, Arthur C. Prior immunization against an intracellular antigen enhances subsequent red blood cell alloimmunization in mice. Blood 2023, 141: 2642-2653. PMID: 36638335, PMCID: PMC10356576, DOI: 10.1182/blood.2022016588.Peer-Reviewed Original ResearchConceptsCD4 T cell responsesT cell responsesIntracellular antigensB cellsImmune primingRed blood cell alloimmunizationBlood cell alloantigensRate of alloimmunizationAdditional alloantibodiesAlloimmunization rateRBC alloantigensSubsequent transfusionsSame alloantigensPrior immunizationTransfusion recipientsDonor RBCsMouse modelNumerous antigensRBC antigensAlloantigensAlloimmunizationAntigenTransfusionAlloantibodiesRBCs
2019
Chapter 57 Platelet Transfusion Refractory Patients
Tormey C, Hendrickson J. Chapter 57 Platelet Transfusion Refractory Patients. 2019, 361-364. DOI: 10.1016/b978-0-12-813726-0.00057-x.ChaptersHuman leukocyte antigenPlatelet refractorinessRefractory patientsPlatelet transfusion-refractory patientsRecipient human leukocyte antigenClass I human leukocyte antigenPlatelet refractory patientsPlatelet transfusion supportManagement of patientsHLA-B antigensCauses of refractorinessHLA alloantibodiesNonimmune causesHost diseaseTransfusion supportLeukocyte antigenOptimal carePatientsClinical teamTransfusion servicesMultidisciplinary approachRefractorinessBlood suppliersPlateletsAntigenChapter 66 Transfusion-Related Acute Lung Injury
Gokhale A, Hendrickson J. Chapter 66 Transfusion-Related Acute Lung Injury. 2019, 405-408. DOI: 10.1016/b978-0-12-813726-0.00066-0.Peer-Reviewed Original ResearchTransfusion-related acute lung injuryTransfusion-associated circulatory overloadAcute lung injuryHuman leukocyte antigenHuman neutrophil antigensLung injuryBlood productsNon-cardiogenic pulmonary edemaAllogeneic blood transfusionTRALI casesCirculatory overloadBlood transfusionSerious complicationsPulmonary edemaNeutrophil antigensClinical syndromeLeukocyte antigenAcute hypoxiaTransfusionInjuryAntigenHypotensionHypertensionComplicationsEdema
2012
Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations
Zimring J, Stowell S, Johnsen J, Hendrickson J. Effects of genetic, epigenetic, and environmental factors on alloimmunization to transfused antigens: Current paradigms and future considerations. Transfusion Clinique Et Biologique 2012, 19: 125-131. PMID: 22682308, DOI: 10.1016/j.tracli.2012.03.002.Peer-Reviewed Original ResearchConceptsImmune systemLarge observational studiesMinority of recipientsHuman immune systemTransfused cellsContext of transfusionRed blood cellsTransfusion therapyObservational studyImmune responseAdditional antibodiesCoagulation factorsAlloimmunizationClinical barriersBlood cellsRecent mechanistic studiesRecipientsTransfusionPatientsPotential causesAntigenAntibodiesMicrobial pathogensCellsResponse