2024
Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells
Geraldo L, Xu Y, Mouthon G, Furtado J, Leser F, Blazer L, Adams J, Zhang S, Zheng L, Song E, Robinson M, Thomas J, Sidhu S, Eichmann A. Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells. Science Translational Medicine 2024, 16: eadn8388. PMID: 39565875, DOI: 10.1126/scitranslmed.adn8388.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCorneal NeovascularizationDisease Models, AnimalHumansIntercellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMyeloid CellsNeovascularization, PathologicNerve Tissue ProteinsReceptors, ImmunologicRetinaRetinal NeovascularizationSignal TransductionConceptsOxygen-induced retinopathyPathological ocular neovascularizationCorneal neovascularizationMyeloid cellsOcular neovascularizationHeterogeneous population of myeloid cellsBlood-retina barrier integrityPopulation of myeloid cellsActivation of myeloid cellsMonoclonal antibodiesOcular neovascular diseasesBlinding eye diseaseHuman monoclonal antibodyExtracellular domainMouse model in vivoModel in vivoMAb treatmentMyeloid populationsOIR retinasNeovascular diseasesVision lossEye diseaseSlit-RoboSlit-Robo signalingBlocking antibodies
2014
Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature
Hallani S, Colin C, Houfi Y, Idbaih A, Boisselier B, Marie Y, Ravassard P, Labussière M, Mokhtari K, Thomas JL, Delattre JY, Eichmann A, Sanson M. Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature. BioMed Research International 2014, 2014: 827327. PMID: 24868550, PMCID: PMC4017715, DOI: 10.1155/2014/827327.Peer-Reviewed Original ResearchAntigens, CDBrain NeoplasmsCadherinsCell DifferentiationCell ProliferationCoculture TechniquesEndoglinEndothelial CellsErbB ReceptorsGene Expression Regulation, NeoplasticGlioblastomaGreen Fluorescent ProteinsHuman Umbilical Vein Endothelial CellsHumansIn Situ Hybridization, FluorescenceLentivirusMicrocirculationNeoplasmsNeovascularization, PathologicPhenotypePlatelet Endothelial Cell Adhesion Molecule-1Receptors, Cell Surface
2013
The power of VEGF (vascular endothelial growth factor) family molecules
Thomas JL, Eichmann A. The power of VEGF (vascular endothelial growth factor) family molecules. Cellular And Molecular Life Sciences 2013, 70: 1673-1674. PMID: 23475064, PMCID: PMC11113691, DOI: 10.1007/s00018-013-1276-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansNeovascularization, PathologicNeurogenesisReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth FactorsInteractions between VEGFR and Notch signaling pathways in endothelial and neural cells
Thomas JL, Baker K, Han J, Calvo C, Nurmi H, Eichmann AC, Alitalo K. Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells. Cellular And Molecular Life Sciences 2013, 70: 1779-1792. PMID: 23479133, PMCID: PMC3648205, DOI: 10.1007/s00018-013-1312-6.Peer-Reviewed Original ResearchMeSH KeywordsEndothelial CellsHumansNeovascularization, PathologicNeurogenesisNeuronsReceptors, NotchReceptors, Vascular Endothelial Growth FactorSignal TransductionVascular Endothelial Growth FactorsConceptsCell fate decisionsDifferent cell contextsTyrosine kinase VEGF receptorsExtracellular matrix moleculesCell interaction mechanismsMetazoan speciesFate decisionsGrowth factorCanonical NotchVascular endothelial growth factorNotch receptorsCell contextEnvironmental cuesDynamic regulationMolecular relationshipsKey regulatorNotch pathwayMatrix moleculesNeural cellsCell contactAdjacent cellsPathwayVEGF receptorsCellsNeurovascular interactions
2011
Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B
Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A. Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B. Developmental Cell 2011, 20: 33-46. PMID: 21238923, DOI: 10.1016/j.devcel.2010.12.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BlockingBlood VesselsCapillary PermeabilityEnzyme ActivationHumansLigandsMiceModels, BiologicalNeovascularization, PathologicNerve Tissue ProteinsNetrin ReceptorsProtein BindingReceptors, Cell SurfaceReceptors, ImmunologicRetinal VesselsSignal TransductionSrc-Family KinasesSus scrofaVascular Endothelial Growth Factor AConceptsProtein-protein interaction screenVascular endothelial growth factorFunction-blocking monoclonal antibodiesInteraction screenNovel functionGuidance receptorsExtracellular domainNetrin receptorsReceptor familyVessel integrityReceptor interactionInhibits angiogenesisRobo4Unexpected interactionsGrowth factorEndothelial cellsUNC5BVascular integrityEndothelial growth factorAngiogenesisIncreases angiogenesisReceptorsMonoclonal antibodiesIntegrityProtein
2010
A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry
Hallani S, Boisselier B, Peglion F, Rousseau A, Colin C, Idbaih A, Marie Y, Mokhtari K, Thomas JL, Eichmann A, Delattre JY, Maniotis AJ, Sanson M. A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry. Brain 2010, 133: 973-982. PMID: 20375132, PMCID: PMC4861203, DOI: 10.1093/brain/awq044.Peer-Reviewed Original ResearchConceptsStem-like cellsGlioblastoma stem-like cellsVascular smooth muscle-like cellsSmooth muscle-like cellsAnti-angiogenic therapyMuscle-like cellsHuman glioblastoma tissuesTransient efficacyTreatment strategiesStem cell propertiesEndothelial proliferationVasculogenic mimicryTumor cellsHuman tumorsBlood vesselsGlioblastoma vasculatureGlioblastoma tissuesGlioblastoma cellsVascularizationCellsDe novoGene expressionNew alternative mechanismTherapyTumors
2007
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis
Larrivée B, Freitas C, Trombe M, Lv X, DeLafarge B, Yuan L, Bouvrée K, Bréant C, Del Toro R, Bréchot N, Germain S, Bono F, Dol F, Claes F, Fischer C, Autiero M, Thomas JL, Carmeliet P, Tessier-Lavigne M, Eichmann A. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes & Development 2007, 21: 2433-2447. PMID: 17908930, PMCID: PMC1993874, DOI: 10.1101/gad.437807.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BFull-length receptorVascular patterningEmbryonic developmentPotential anti-angiogenic targetCell repulsionGenetic lossSprouting angiogenesisAdult vasculaturePathological angiogenesisReceptor UNC5BUNC5B receptorUNC5BAnti-angiogenic targetAxonal growthAngiogenesisNetrin-1InhibitsActivation inhibitsReceptorsNetrinAngiogenesis inhibitionPatterningMatrigelIntracellular