2015
Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization
Dubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A. Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization. Circulation 2015, 133: 409-421. PMID: 26659946, PMCID: PMC4729599, DOI: 10.1161/circulationaha.115.017537.Peer-Reviewed Original ResearchConceptsFront-rear polaritySprouting angiogenesisSignal integration mechanismImportant drug targetsNck adaptorsCytoskeletal dynamicsEndothelial cell migrationEmbryonic developmentAngiogenesis defectsPAK2 activationVessel sproutsNumber of diseasesBlood vessel growthDrug targetsCell migrationPostnatal retinaAngiogenic growthNckNck1AdaptorVessel growthKey processesEndothelial cellsPathological ocular neovascularizationInhibits neovascularization
2000
RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.
Traver S, Bidot C, Spassky N, Baltauss T, De Tand M, Thomas J, Zalc B, Janoueix-Lerosey I, Gunzburg J. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochemical Journal 2000, 350 Pt 1: 19-29. PMID: 10926822, PMCID: PMC1221220, DOI: 10.1042/0264-6021:3500019.Peer-Reviewed Original ResearchConceptsGTPase activityRap effectorRGS proteinsRas/RapTwo-hybrid systemHeterotrimeric G proteinsRaf-1 kinaseG protein-coupled receptorsSitu hybridization experimentsRap proteinsGTPase Rap2Galpha subunitsHeterotrimeric proteinDeletion analysisDomain sharesRGS14Hybridization experimentsRap2B-RafAlpha subunitG proteinsProteinSitu hybridization studiesCertain cellsHybridization studies