2011
A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells
Lamprianou S, Chatzopoulou E, Thomas J, Bouyain S, Harroch S. A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 17498-17503. PMID: 21969550, PMCID: PMC3198311, DOI: 10.1073/pnas.1108774108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell DifferentiationCell ProliferationContactin 1Crystallography, X-RayHumansMiceMice, KnockoutModels, MolecularModels, NeurologicalMultiprotein ComplexesNeural Stem CellsNeurogenesisOligodendrogliaProtein Structure, TertiaryReceptor-Like Protein Tyrosine Phosphatases, Class 5Recombinant ProteinsSolubilityConceptsCarbonic anhydrase-like domainPrecursor cellsReceptor protein tyrosineOligodendrocyte precursor cellsPtprz-deficient miceProtein tyrosineCell adhesion moleculeNeural cell adhesion moleculeBiological roleContactin familyCocrystal structureGlial cell populationsUnknown modulatorsPtprzCentral nervous systemCell populationsCNTN1Structural dataAdhesion moleculesBindsContactin-1CellsMature oligodendrocytesComplexesNervous system
2000
RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.
Traver S, Bidot C, Spassky N, Baltauss T, De Tand M, Thomas J, Zalc B, Janoueix-Lerosey I, Gunzburg J. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochemical Journal 2000, 350 Pt 1: 19-29. PMID: 10926822, PMCID: PMC1221220, DOI: 10.1042/0264-6021:3500019.Peer-Reviewed Original ResearchConceptsGTPase activityRap effectorRGS proteinsRas/RapTwo-hybrid systemHeterotrimeric G proteinsRaf-1 kinaseG protein-coupled receptorsSitu hybridization experimentsRap proteinsGTPase Rap2Galpha subunitsHeterotrimeric proteinDeletion analysisDomain sharesRGS14Hybridization experimentsRap2B-RafAlpha subunitG proteinsProteinSitu hybridization studiesCertain cellsHybridization studies