2007
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis
Larrivée B, Freitas C, Trombe M, Lv X, DeLafarge B, Yuan L, Bouvrée K, Bréant C, Del Toro R, Bréchot N, Germain S, Bono F, Dol F, Claes F, Fischer C, Autiero M, Thomas JL, Carmeliet P, Tessier-Lavigne M, Eichmann A. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes & Development 2007, 21: 2433-2447. PMID: 17908930, PMCID: PMC1993874, DOI: 10.1101/gad.437807.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BFull-length receptorVascular patterningEmbryonic developmentPotential anti-angiogenic targetCell repulsionGenetic lossSprouting angiogenesisAdult vasculaturePathological angiogenesisReceptor UNC5BUNC5B receptorUNC5BAnti-angiogenic targetAxonal growthAngiogenesisNetrin-1InhibitsActivation inhibitsReceptorsNetrinAngiogenesis inhibitionPatterningMatrigelIntracellular
2004
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Lu X, le Noble F, Yuan L, Jiang Q, de Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004, 432: 179-186. PMID: 15510105, DOI: 10.1038/nature03080.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BEndothelial tip cell filopodiaTip cell filopodiaReceptor UNC5BEndothelial tip cellsVascular systemNetrin-1aTip cellsEndothelial cellsProper wiringAxon guidanceCell filopodiaNetrin receptorsGuidance eventsFilopodial retractionMorphogenesisUNC5BVessel branchingAberrant extensionAnatomical similaritiesNetrin-1CellsZebrafishGenesGuidance function