2010
Nitric Oxide Plays a Key Role in Myelination in the Developing Brain
Olivier P, Loron G, Fontaine R, Pansiot J, Dalous J, Thi H, Charriaut-Marlangue C, Thomas J, Mercier J, Gressens P, Baud O. Nitric Oxide Plays a Key Role in Myelination in the Developing Brain. Journal Of Neuropathology & Experimental Neurology 2010, 69: 828-837. PMID: 20613635, DOI: 10.1097/nen.0b013e3181ea5203.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAge FactorsAnimalsAnimals, NewbornAntigensBehavioral SymptomsBrainCell ProliferationCentral Nervous SystemDose-Response Relationship, DrugEnzyme InhibitorsExploratory BehaviorFemaleFree Radical ScavengersGene Expression Regulation, DevelopmentalIn Situ Nick-End LabelingKi-67 AntigenMaleMiceMice, Inbred C57BLMyelin Basic ProteinMyelin Proteolipid ProteinNerve Fibers, MyelinatedNerve Tissue ProteinsNeuronsNeuropsychological TestsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIO AntigensOligodendrogliaProteoglycansRatsRats, Sprague-DawleySpace PerceptionSpatial BehaviorStatistics, NonparametricConceptsEndogenous NONitric oxide synthase inhibitor N-nitro-L-arginine methyl esterN-nitro-L-arginine methyl esterL-NAME-treated animalsNitric oxidePerinatal brain damageSubsequent behavioral deficitsCentral nervous system myelinationNeonatal exposureC57BL/6 miceNeonatal periodBrain damagePromising therapyBehavioral deficitsMouse pupsImmature oligodendrocytesPotential new avenuesWhite matterLow dosesProliferative effectMyelination defectsMyelinationTransient increaseINODeleterious effects
2007
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis
Larrivée B, Freitas C, Trombe M, Lv X, DeLafarge B, Yuan L, Bouvrée K, Bréant C, Del Toro R, Bréchot N, Germain S, Bono F, Dol F, Claes F, Fischer C, Autiero M, Thomas JL, Carmeliet P, Tessier-Lavigne M, Eichmann A. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes & Development 2007, 21: 2433-2447. PMID: 17908930, PMCID: PMC1993874, DOI: 10.1101/gad.437807.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BFull-length receptorVascular patterningEmbryonic developmentPotential anti-angiogenic targetCell repulsionGenetic lossSprouting angiogenesisAdult vasculaturePathological angiogenesisReceptor UNC5BUNC5B receptorUNC5BAnti-angiogenic targetAxonal growthAngiogenesisNetrin-1InhibitsActivation inhibitsReceptorsNetrinAngiogenesis inhibitionPatterningMatrigelIntracellular