2018
Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8
Marie C, Clavairoly A, Frah M, Hmidan H, Yan J, Zhao C, Van Steenwinckel J, Daveau R, Zalc B, Hassan B, Thomas JL, Gressens P, Ravassard P, Moszer I, Martin DM, Lu QR, Parras C. Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e8246-e8255. PMID: 30108144, PMCID: PMC6126750, DOI: 10.1073/pnas.1802620115.Peer-Reviewed Original ResearchConceptsChromatin remodelersProliferation-differentiation balanceNormal developmentChromatin accessibility analysisOligodendrocyte precursor cellsChromatin closingChromatin remodelingChromatin openingTranscriptional repressionGenetic interactionsUncharacterized functionGenetic reprogrammingRisk-associated genesTranscriptional activationKey regulatorNeurodevelopmental defectsPrecursor survivalLineage cellsCHD7RemodelersOligodendrocyte lineage cellsPrecursor cellsGlioma formationBinding profileCHD8
2015
Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination
Sekizar S, Mannioui A, Azoyan L, Colin C, Thomas JL, Du Pasquier D, Mallat M, Zalc B. Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination. Developmental Neuroscience 2015, 37: 232-242. PMID: 25896276, DOI: 10.1159/000380817.Peer-Reviewed Original Research
2013
Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination
Nakatani H, Martin E, Hassani H, Clavairoly A, Maire CL, Viadieu A, Kerninon C, Delmasure A, Frah M, Weber M, Nakafuku M, Zalc B, Thomas JL, Guillemot F, Nait-Oumesmar B, Parras C. Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination. Journal Of Neuroscience 2013, 33: 9752-9768. PMID: 23739972, PMCID: PMC3892435, DOI: 10.1523/jneurosci.0805-13.2013.Peer-Reviewed Original ResearchConceptsOligodendrocyte precursor cellsNeonatal periodCortical oligodendrocyte precursor cellsOligodendrocyte developmentCortical subventricular zoneSubventricular zone progenitorsMultiple sclerosis lesionsMyelin-forming cellsPostnatal cortexRemyelination processFocal demyelinationCorpus callosumSubventricular zoneOPC differentiationPostnatal brainMouse modelAscl1 functionOligodendrogenesisOPC developmentSclerosis lesionsASCL1 expressionCortical progenitorsRemyelinationProneural transcription factorsOligodendrocytes
2011
A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells
Lamprianou S, Chatzopoulou E, Thomas J, Bouyain S, Harroch S. A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 17498-17503. PMID: 21969550, PMCID: PMC3198311, DOI: 10.1073/pnas.1108774108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell DifferentiationCell ProliferationContactin 1Crystallography, X-RayHumansMiceMice, KnockoutModels, MolecularModels, NeurologicalMultiprotein ComplexesNeural Stem CellsNeurogenesisOligodendrogliaProtein Structure, TertiaryReceptor-Like Protein Tyrosine Phosphatases, Class 5Recombinant ProteinsSolubilityConceptsCarbonic anhydrase-like domainPrecursor cellsReceptor protein tyrosineOligodendrocyte precursor cellsPtprz-deficient miceProtein tyrosineCell adhesion moleculeNeural cell adhesion moleculeBiological roleContactin familyCocrystal structureGlial cell populationsUnknown modulatorsPtprzCentral nervous systemCell populationsCNTN1Structural dataAdhesion moleculesBindsContactin-1CellsMature oligodendrocytesComplexesNervous system
2007
Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?
Williams A, Piaton G, Aigrot MS, Belhadi A, Théaudin M, Petermann F, Thomas JL, Zalc B, Lubetzki C. Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis? Brain 2007, 130: 2554-2565. PMID: 17855378, DOI: 10.1093/brain/awm202.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsApoptosisCerebral CortexDisease Models, AnimalFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiddle AgedMotor CortexMultiple SclerosisMyelin SheathNerve RegenerationNerve Tissue ProteinsNeurogliaNeuronsRatsRats, WistarRNA, MessengerSemaphorin-3ASignal TransductionUp-RegulationConceptsMultiple sclerosisSemaphorin 3AAbility of plaqueActive demyelinating lesionsNeuronal cell bodiesFailure of repairCentral nervous systemOligodendrocyte precursor cellsOligodendrocyte precursor cell migrationPrecursor cell migrationChronic plaquesDemyelinating lesionsDemyelinated plaquesMyelin repairDemyelinated axonsMS tissueNervous systemCell bodiesExperimental modelPlaquesLesionsPrecursor cellsSclerosisOligodendroglial migrationCell migration
2006
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nature Neuroscience 2006, 9: 340-348. PMID: 16462734, DOI: 10.1038/nn1646.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCells, CulturedEvolution, MolecularIntermediate Filament ProteinsLarvaLateral VentriclesMiceMice, KnockoutMice, TransgenicNerve Growth FactorsNerve Tissue ProteinsNestinNeuronsOligodendrogliaOptic NerveRatsRats, WistarStem CellsVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3Xenopus laevisConceptsNeural progenitor cellsReceptor VEGFR-3Mouse embryosNeural progenitorsVEGFR-3Progenitor cellsVertebrate embryonic brainBlood vessel defectsOligodendrocyte precursor cellsXenopus laevisAction of VEGFEmbryonic brainVascular endothelial growth factor CVEGF-C knockdownNeural cellsPrecursor cellsVessel defectsFactor CEmbryosGrowth factorProgenitorsCellsProliferation of OPCsVascular systemLymphatic vessels
2004
Control of axonophilic migration of oligodendrocyte precursor cells by Eph-ephrin interaction.
Prestoz L, Chatzopoulou E, Lemkine G, Spassky N, Lebras B, Kagawa T, Ikenaka K, Zalc B, Thomas JL. Control of axonophilic migration of oligodendrocyte precursor cells by Eph-ephrin interaction. Neuron Glia Biology 2004, 1: 73-83. PMID: 18634608, DOI: 10.1017/s1740925x04000109.Peer-Reviewed Original Research
2002
Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1
Spassky N, de Castro F, Le Bras B, Heydon K, Quéraud-LeSaux F, Bloch-Gallego E, Chédotal A, Zalc B, Thomas J. Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1. Journal Of Neuroscience 2002, 22: 5992-6004. PMID: 12122061, PMCID: PMC6757938, DOI: 10.1523/jneurosci.22-14-05992.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesCell DivisionCell LineCell LineageCell MovementChemotaxisCulture TechniquesDCC ReceptorGlycoproteinsHumansMembrane ProteinsMiceNerve Growth FactorsNerve Tissue ProteinsNetrin ReceptorsNetrin-1Neuropilin-1OligodendrogliaOptic NerveReceptors, Cell SurfaceSemaphorin-3AStem CellsTumor Suppressor ProteinsConceptsOligodendrocyte precursor cellsEmbryonic optic nerveMigration of OPCsOptic nerveNetrin-1Sema 3ANetrin-1 receptorWhite matter tractsSema 3FMyelin-forming cellsColorectal cancerClass 3 semaphorinsLocalization of cellsNerveChemotactic effectNeuropilin-1Multiple fociFunctional migrationPrecursor cellsNetrin familyOligodendroglial migrationSemaphorinsNeural tubeDual effectGuidance cues
2000
Spatiotemporal development of oligodendrocytes in the embryonic brain
Thomas J, Spassky N, Villegas E, Olivier C, Cobos I, Goujet‐Zalc C, Martínez S, Zalc B. Spatiotemporal development of oligodendrocytes in the embryonic brain. Journal Of Neuroscience Research 2000, 59: 471-476. PMID: 10679785, DOI: 10.1002/(sici)1097-4547(20000215)59:4<471::aid-jnr1>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsCentral nervous systemOligodendrocyte precursor cellsPrecursor cellsNeural tubeSite of originSubventricular zoneNervous systemVentricular layerOligodendrocyte precursorsFirst neuronsOligodendrocyte progenitorsOligodendrocytesEmbryonic brainRostrocaudal axisLast cell typeQuail-chick chimerasProgenitor cellsRecent dataBrainCell typesMosaic populationProgenitor stageCellsNeurons