2024
Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice
Thomas J, Schindler E, Gottschalk C. Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice. Journal Of Clinical Investigation 2024, 134: e182556. PMID: 39087472, PMCID: PMC11290958, DOI: 10.1172/jci182556.Peer-Reviewed Original ResearchConceptsBlocking CGRP signalingCGRP receptor componentsMigraine-like painCervical lymph nodesGap junction proteinPrimary headache disordersLymphatic vessel dysfunctionAcute migrainePharmacological blockadeLymph nodesHeadache disordersNeurological symptomsJunction proteinsCGRPLymphatic vesselsMeningeal lymphatic vesselsInducible knockoutVessel dysfunctionMigraineReceptor componentsHeadachePainPathophysiologyDysfunctionMice
2014
Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1
Patterson VL, Zullo AJ, Koenig C, Stoessel S, Jo H, Liu X, Han J, Choi M, DeWan AT, Thomas JL, Kuan CY, Hoh J. Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1. PLOS ONE 2014, 9: e115789. PMID: 25531304, PMCID: PMC4274161, DOI: 10.1371/journal.pone.0115789.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBehavior, AnimalBlotting, WesternCell ProliferationCerebellumFemaleGTP PhosphohydrolasesHigh-Temperature Requirement A Serine Peptidase 2MaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial ProteinsNerve DegenerationNeuronsParkinson DiseaseReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSequence DeletionSerine EndopeptidasesSignal TransductionConceptsNeural-specific deletionStriatal neuronal lossPostnatal day 18Days of ageNeuronal lossNeurological symptomsParkinson's diseaseMouse modelParkinsonian phenotypeSystemic effectsMitochondrial Opa1Day 18Premature deathMutant miceNeural contributionsMiceCerebellar neurodegenerationKey moleculesStructural anomaliesAbnormal activityAbnormal morphologyCerebellumDiseaseComplete penetranceDeath
2010
Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3
Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A. Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3. Journal Of Cell Biology 2010, 188: 115-130. PMID: 20065093, PMCID: PMC2812843, DOI: 10.1083/jcb.200903137.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ShapeCells, CulturedEndothelial CellsFemaleLymphangiogenesisLymphatic VesselsMaleMiceMice, Inbred C57BLMice, Inbred StrainsMice, TransgenicNeuropilin-2Protein BindingVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factor Receptor-3ConceptsLymphatic vessel sproutingVEGF receptor 2Lymphangiogenic vascular endothelial growth factors CSprouting defectsNeuropilin-2Vessel sproutingVascular endothelial growth factor CVEGF-C bindingAntibody treatmentEndothelial tip cellsReceptor 2Lymph vesselsLymphatic sproutingGenetic deletionHeterozygous miceTransmembrane receptorsTip cellsAdult organsMiceCell extensionsNRP2Vascular systemVascular sprout formationVascular sproutingVEGF
2008
Genetic tracing of subpopulation neurons in the prethalamus of mice (Mus musculus)
Delaunay D, Heydon K, Miguez A, Schwab M, Nave K, Thomas J, Spassky N, Martinez S, Zalc B. Genetic tracing of subpopulation neurons in the prethalamus of mice (Mus musculus). The Journal Of Comparative Neurology 2008, 512: 74-83. PMID: 18973275, DOI: 10.1002/cne.21904.Peer-Reviewed Original ResearchConceptsVentral lateral geniculateCre/lox reporter systemGFP reporter miceGABAergic cellsGABAergic neuronsGlutamatergic neuronsLateral geniculateZona incertaHypothalamic nucleiSubthalamic nucleusReporter miceZona limitans intrathalamicaVentricular cellsIntergeniculate leafletNeuronsProgenitor cellsPosterior partGenetic tracingDiencephalonPool of progenitorsGenetic labelingPLP transcriptsMiceBasal plateCells
2004
Evaluation of Hematopoietic Potential Generated by Transplantation of Muscle-Derived Stem Cells in Mice
Farace F, Prestoz L, Badaoui S, Guillier M, Haond C, Opolon P, Thomas JL, Zalc B, Vainchenker W, Turhan AG. Evaluation of Hematopoietic Potential Generated by Transplantation of Muscle-Derived Stem Cells in Mice. Stem Cells And Development 2004, 13: 83-92. PMID: 15068696, DOI: 10.1089/154732804773099281.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesBone Marrow CellsBone Marrow TransplantationCell DivisionCell LineageCell SeparationCell TransplantationChimeraFemaleFlow CytometryHematopoiesisHematopoietic Stem CellsHematopoietic SystemIn Situ Hybridization, FluorescenceKiller Cells, NaturalLeukocyte Common AntigensMaleMiceMice, Inbred C57BLMusclesPolymerase Chain ReactionSex FactorsStem CellsT-LymphocytesConceptsMarrow transplantationUse of muscleStem cellsTransplantation of musclesNatural killer cellsMarrow-derived stem cellsMuscle-derived hematopoietic stem cellsLevel of CFUMuscle-derived stem cellsMarrow stem cellsMuscle tissueMuscle transplantsKiller cellsTertiary recipientsHematopoietic chimerismMuscle graftsIrradiated miceAdult miceTransplantationHematopoietic stem cellsSecondary recipientsSimilar potencyMiceMurine muscleSerial transplantation
1998
Multiple Restricted Origin of Oligodendrocytes
Spassky N, Goujet-Zalc C, Parmantier E, Olivier C, Martinez S, Ivanova A, Ikenaka K, Macklin W, Cerruti I, Zalc B, Thomas J. Multiple Restricted Origin of Oligodendrocytes. Journal Of Neuroscience 1998, 18: 8331-8343. PMID: 9763477, PMCID: PMC6792828, DOI: 10.1523/jneurosci.18-20-08331.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta-GalactosidaseBiomarkersBleomycinBrain ChemistryCell DifferentiationCell LineageCells, CulturedCentral Nervous SystemCloning, MolecularDNA-Binding ProteinsDrug Resistance, MicrobialFemaleGene Expression Regulation, DevelopmentalLac OperonMaleMiceMice, TransgenicNeuronsOligodendrogliaReceptors, Platelet-Derived Growth FactorStem CellsTranscription FactorsTransgenes