Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination
das Neves S, Delivanoglou N, Ren Y, Cucuzza C, Makuch M, Almeida F, Sanchez G, Barber M, Rego S, Schrader R, Faroqi A, Thomas J, McLean P, Oliveira T, Irani S, Piehl F, Da Mesquita S. Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination. Immunity 2024, 57: 2328-2343.e8. PMID: 39217987, PMCID: PMC11464205, DOI: 10.1016/j.immuni.2024.08.004.Peer-Reviewed Original ResearchLymphatic functionMeningeal lymphatic dysfunctionLymphatic dysfunctionVascular endothelial growth factor-CState of immunosuppressionMyeloid cell activationHuman demyelinating diseasesBrain myelinMature oligodendrocyte numbersClinical relapseImmunocompetent miceAdult miceMeningeal lymphatic functionAxonal lossOligodendrocyte survivalDemyelinating diseaseOligodendrocyte numbersVessel ablationAdaptive immunityCell activationCerebrospinal fluidGene expression changesMature oligodendrocytesOligodendrocyte functionGlial cells