2013
The power of VEGF (vascular endothelial growth factor) family molecules
Thomas JL, Eichmann A. The power of VEGF (vascular endothelial growth factor) family molecules. Cellular And Molecular Life Sciences 2013, 70: 1673-1674. PMID: 23475064, PMCID: PMC11113691, DOI: 10.1007/s00018-013-1276-6.Peer-Reviewed Original ResearchInteractions between VEGFR and Notch signaling pathways in endothelial and neural cells
Thomas JL, Baker K, Han J, Calvo C, Nurmi H, Eichmann AC, Alitalo K. Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells. Cellular And Molecular Life Sciences 2013, 70: 1779-1792. PMID: 23479133, PMCID: PMC3648205, DOI: 10.1007/s00018-013-1312-6.Peer-Reviewed Original ResearchConceptsCell fate decisionsDifferent cell contextsTyrosine kinase VEGF receptorsExtracellular matrix moleculesCell interaction mechanismsMetazoan speciesFate decisionsGrowth factorCanonical NotchVascular endothelial growth factorNotch receptorsCell contextEnvironmental cuesDynamic regulationMolecular relationshipsKey regulatorNotch pathwayMatrix moleculesNeural cellsCell contactAdjacent cellsPathwayVEGF receptorsCellsNeurovascular interactions
2012
Molecular Parallels between Neural and Vascular Development
Eichmann A, Thomas JL. Molecular Parallels between Neural and Vascular Development. Cold Spring Harbor Perspectives In Medicine 2012, 3: a006551. PMID: 23024177, PMCID: PMC3530036, DOI: 10.1101/cshperspect.a006551.Peer-Reviewed Original ResearchConceptsCentral nervous systemAdult neurogenic nichesMolecular parallelsNeural stem cellsCardiac outputMolecular mechanismsBlood vesselsNeurovascular interactionsVascular developmentHuman diseasesStem cellsCNS blood vesselsHuman central nervous systemBlood-brain barrierVascular endothelial growth factorNeurogenic nicheCell populationsEndothelial growth factorGrowth factorEndothelial cellsBlood glucoseNervous systemImportant roleCellsUnique population
2011
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis
Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas JL. Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. Genes & Development 2011, 25: 831-844. PMID: 21498572, PMCID: PMC3078708, DOI: 10.1101/gad.615311.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedEnzyme-Linked Immunosorbent AssayImmunohistochemistryLymphangiogenesisMiceMice, Mutant StrainsMicroscopy, Electron, TransmissionNeovascularization, PhysiologicNeural Stem CellsNeurogenesisOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionVascular Endothelial Growth Factor Receptor-3ConceptsNeural stem cellsSubventricular zoneVEGF receptorsNeural cellsVEGFR-3Vascular endothelial growth factor (VEGF) familyEndothelial growth factor familyVascular endothelial growth factor receptor 3VEGFR-3 expressionMultipotent neural stem cellsCapillary endothelial cellsGrowth factor receptor 3Overexpression of VEGFGrowth factor familyAdult neurogenesisSVZ neurogenesisReporter miceReceptor 3NeurogenesisNeurodegenerative diseasesConditional deletionEndothelial cellsGrowth factorLigand VEGFInducible deletionRobo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B
Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A. Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B. Developmental Cell 2011, 20: 33-46. PMID: 21238923, DOI: 10.1016/j.devcel.2010.12.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BlockingBlood VesselsCapillary PermeabilityEnzyme ActivationHumansLigandsMiceModels, BiologicalNeovascularization, PathologicNerve Tissue ProteinsNetrin ReceptorsProtein BindingReceptors, Cell SurfaceReceptors, ImmunologicRetinal VesselsSignal TransductionSrc-Family KinasesSus scrofaVascular Endothelial Growth Factor AConceptsProtein-protein interaction screenVascular endothelial growth factorFunction-blocking monoclonal antibodiesInteraction screenNovel functionGuidance receptorsExtracellular domainNetrin receptorsReceptor familyVessel integrityReceptor interactionInhibits angiogenesisRobo4Unexpected interactionsGrowth factorEndothelial cellsUNC5BVascular integrityEndothelial growth factorAngiogenesisIncreases angiogenesisReceptorsMonoclonal antibodiesIntegrityProtein
2008
A novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors
Bribián A, Esteban P, Clemente D, Soussi‐Yanicostas N, Thomas J, Zalc B, de Castro F. A novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors. Developmental Neurobiology 2008, 68: 1503-1516. PMID: 18814310, DOI: 10.1002/dneu.20678.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntibodiesCell AdhesionCell MovementCells, CulturedChemotactic FactorsCollagenCricetinaeCricetulusEmbryo, MammalianExtracellular Matrix ProteinsFibroblast Growth Factor 2GangliosidesGene Expression Regulation, DevelopmentalMiceNerve Tissue ProteinsOligodendrogliaReceptor, Fibroblast Growth Factor, Type 1RetinaRNA, MessengerStem CellsConceptsOptic nerveOligodendrocyte precursorsEntire optic nerveEmbryonic optic nerveRetinal ganglion cellsAnosmin-1Ganglion cellsPreoptic areaCell adhesion moleculeOPC migrationGrowth factorAdhesion moleculesFGF-2Novel roleGuidance cuesFGFR1Soluble formImpairsCellsECM moleculesNovel effectNerveBlockadeEmbryonic stagesAxons
2006
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nature Neuroscience 2006, 9: 340-348. PMID: 16462734, DOI: 10.1038/nn1646.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCells, CulturedEvolution, MolecularIntermediate Filament ProteinsLarvaLateral VentriclesMiceMice, KnockoutMice, TransgenicNerve Growth FactorsNerve Tissue ProteinsNestinNeuronsOligodendrogliaOptic NerveRatsRats, WistarStem CellsVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3Xenopus laevisConceptsNeural progenitor cellsReceptor VEGFR-3Mouse embryosNeural progenitorsVEGFR-3Progenitor cellsVertebrate embryonic brainBlood vessel defectsOligodendrocyte precursor cellsXenopus laevisAction of VEGFEmbryonic brainVascular endothelial growth factor CVEGF-C knockdownNeural cellsPrecursor cellsVessel defectsFactor CEmbryosGrowth factorProgenitorsCellsProliferation of OPCsVascular systemLymphatic vessels