2020
Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex
Werling DM, Pochareddy S, Choi J, An JY, Sheppard B, Peng M, Li Z, Dastmalchi C, Santpere G, Sousa AMM, Tebbenkamp ATN, Kaur N, Gulden FO, Breen MS, Liang L, Gilson MC, Zhao X, Dong S, Klei L, Cicek AE, Buxbaum JD, Adle-Biassette H, Thomas JL, Aldinger KA, O’Day D, Glass IA, Zaitlen NA, Talkowski ME, Roeder K, State MW, Devlin B, Sanders SJ, Sestan N. Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex. Cell Reports 2020, 31: 107489. PMID: 32268104, PMCID: PMC7295160, DOI: 10.1016/j.celrep.2020.03.053.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBrainComputational BiologyDatabases, GeneticExome SequencingGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenomicsHumansPhenotypePolymorphism, Single NucleotidePrefrontal CortexQuantitative Trait LociSequence Analysis, RNATranscriptomeWhole Genome SequencingConceptsExpression levelsGene expression levelsTranscriptomic coordinationDisorder lociNeuropsychiatric traitsSpecific genesRisk lociGene expressionGenomic variantsDevelopmental stagesCell typesGenesLociTissue RNACommon variantsPostnatal stagesUnique resourceSpecific variantsExpressionEQTLsVariantsGenomeHuman prefrontal cortexRNATraits
2019
RNA Profiling of the Human and Mouse Spinal Cord Stem Cell Niches Reveals an Embryonic-like Regionalization with MSX1+ Roof-Plate-Derived Cells
Ghazale H, Ripoll C, Leventoux N, Jacob L, Azar S, Mamaeva D, Glasson Y, Calvo CF, Thomas JL, Meneceur S, Lallemand Y, Rigau V, Perrin FE, Noristani HN, Rocamonde B, Huillard E, Bauchet L, Hugnot JP. RNA Profiling of the Human and Mouse Spinal Cord Stem Cell Niches Reveals an Embryonic-like Regionalization with MSX1+ Roof-Plate-Derived Cells. Stem Cell Reports 2019, 12: 1159-1177. PMID: 31031189, PMCID: PMC6524006, DOI: 10.1016/j.stemcr.2019.04.001.Peer-Reviewed Original ResearchConceptsTranscription factorsRNA profilingDevelopmental transcription factorsDorsal-ventral patternStem cell nicheEpendymal zoneMolecular resourcesMammalian lesionsConserved expressionCell nicheNeural stem cellsCell diversityPossible endogenous sourceQuiescent cellsGenesFloor plateStem cellsMsx1Endogenous sourcesTransgenic miceCellsProfilingSpinal cordCentral canalExpression
2011
Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube
Di Lullo E, Haton C, Le Poupon C, Volovitch M, Joliot A, Thomas JL, Prochiantz A. Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development 2011, 138: 4991-5001. PMID: 22028031, DOI: 10.1242/dev.066282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell DifferentiationCell MovementChick EmbryoExtracellular SpaceEye ProteinsHomeodomain ProteinsNerve Tissue ProteinsNeural TubeOligodendrogliaPaired Box Transcription FactorsParacrine CommunicationPAX6 Transcription FactorProtein TransportRepressor ProteinsStem CellsSubstrate SpecificityTissue DistributionConceptsPrecursor cell migrationPax6 proteinPax6 activityChick embryonic neural tubeNeural tubeCell migrationChick neural tubeOligodendrocyte precursor cell migrationEmbryonic neural tubeHomeoprotein transcription factorOPC migrationGene transfer experimentsEmbryonic polarityTranscription factorsIntercellular transferExtracellular expressionPhysiological importancePax6Visual cortex plasticityProteinFundamental rolePossible roleParacrine effectsExpressionPax6 antibodies
2001
The Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents
Spassky N, Olivier C, Cobos I, LeBras B, Goujet-Zalc C, Martínez S, Zalc B, Thomas J. The Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents. Developmental Neuroscience 2001, 23: 318-326. PMID: 11756747, DOI: 10.1159/000048715.Peer-Reviewed Original ResearchConceptsOligodendroglial genesBrain of chicksCentral nervous systemMyelin-forming cellsSpinal cordPrimitive progenitor cellsNervous systemRodent brainOligodendroglial markersOligodendrocyte lineageEmbryonic brainProgenitor cellsBrainOligodendrogenesisCell lineagesProgenitor stageCellsChicksCordExpressionEarly stepsOligodendrocytes
1997
PMP‐22 expression in the central nervous system of the embryonic mouse defines potential transverse segments and longitudinal columns
Parmantier E, Braun C, Thomas J, Peyron F, Martinez S, Zalc B. PMP‐22 expression in the central nervous system of the embryonic mouse defines potential transverse segments and longitudinal columns. The Journal Of Comparative Neurology 1997, 378: 159-172. PMID: 9120057, DOI: 10.1002/(sici)1096-9861(19970210)378:2<159::aid-cne1>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsCentral nervous systemCranial nerve motor nucleiSpinal cordPMP-22Motor nucleusNervous systemVentricular zoneCaudo-rostral axisPeripheral nervous system myelinEarly postnatal developmentRostro-caudal gradientVentral spinal cordPostnatal developmentCordMesencephalonEmbryonic miceEmbryonic daySystem myelinMotoneuronsLongitudinal columnsTransverse segmentsProsencephalonRoof plateForebrain organizationExpression