2019
Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone
Matta R, Lee S, Genet N, Hirschi KK, Thomas JL, Gonzalez AL. Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone. Scientific Reports 2019, 9: 17798. PMID: 31780709, PMCID: PMC6882840, DOI: 10.1038/s41598-019-54167-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell EncapsulationCell LineCell ProliferationCell SurvivalEndothelial CellsLateral VentriclesMaleMatrix MetalloproteinasesMiceMice, Inbred C57BLMicrospheresNeural Stem CellsNeuronsPolyethylene GlycolsRecovery of FunctionStem Cell NicheStem Cell TransplantationConceptsEndothelial cellsSubventricular zoneNSC quiescenceNon-injury modelQuiescent neural stem cellsAdult subventricular zoneNeuronal stem cellsStem cellsNeural stem cellsFunctional recoveryNeurological injuryInflammatory responseNeural stem cell maintenanceNSC deliveryNeural tissue repairNeurological diseasesMouse brainCell therapyNSC viabilityBrainTissue repairInjuryCo-encapsulated cellsSurvivalDelivery
2016
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging
Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging. ACS Nano 2016, 10: 4209-4218. PMID: 26967254, PMCID: PMC5257033, DOI: 10.1021/acsnano.5b07573.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBiological TransportBlood-Brain BarrierBrain NeoplasmsCell Line, TumorDecanoic AcidsDrug Delivery SystemsEthanolaminesFemaleGenetic TherapyHeterograftsHumansMatrix Metalloproteinase 2MiceMice, Inbred C57BLNanoparticlesOptical ImagingPaclitaxelPermeabilityPolymersPurinesPyrazolesScorpion VenomsTranscytosisTumor MicroenvironmentConceptsBlood-brain barrierLow delivery efficiencyTransport of nanoparticlesCancer gene therapyNanoparticle deliveryMore nanoparticlesBrain tumorsNanoparticlesDelivery efficiencyGene therapySystemic deliveryNPsBrain malignanciesBBB modulatorsPharmacological agentsBrain cancerBrain regionsTumorsDeliveryBrainImproved treatmentInadequate amountsPositive feedback loopChemotherapyMalignancy