Synthesis and Structure–Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold
Li Z, Ishida R, Liu Y, Wang J, Li Y, Gao Y, Jiang J, Che J, Sheltzer JM, Robers MB, Zhang T, Westover KD, Nabet B, Gray NS. Synthesis and Structure–Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold. European Journal Of Medicinal Chemistry 2022, 238: 114433. PMID: 35597007, PMCID: PMC9477540, DOI: 10.1016/j.ejmech.2022.114433.Peer-Reviewed Original ResearchConceptsCyclin-dependent kinasesCell cycle regulationG2/M cell cycle arrestM cell cycle arrestCell cycle arrestCellular functionsCycle regulationCellular assaysCycle arrestTool compoundsNeuronal functionAttractive targetCDK11Drug discoveryMedicinal chemistry modificationsStructure-activity relationshipsSplicingTranscriptionInhibitorsMedicinal chemistry campaignKinaseInhibitionApoptosisMRNARegulation