2022
Extensive protein dosage compensation in aneuploid human cancers
Schukken KM, Sheltzer J. Extensive protein dosage compensation in aneuploid human cancers. Genome Research 2022, 32: 1254-1270. PMID: 35701073, PMCID: PMC9341510, DOI: 10.1101/gr.276378.121.Peer-Reviewed Original ResearchConceptsDosage compensationPost-translational regulatory mechanismsProtein complex subunitsCopy numberHuman cancersCell cycle genesEffects of aneuploidyMajority of proteinsChromosome copy numberProtein expression dataKey driver genesChromosome copy number changesExpression of oncogenesCopy number changesKey cancer driversComplex subunitsCycle genesGene groupsCancer driversCancer proteomeRegulatory mechanismsTumor suppressorExpression dataDriver genesChromosome gains
2017
Single-chromosome Gains Commonly Function as Tumor Suppressors
Sheltzer J, Ko J, Replogle J, Burgos N, Chung E, Meehl C, Sayles N, Passerini V, Storchova Z, Amon A. Single-chromosome Gains Commonly Function as Tumor Suppressors. Cancer Cell 2017, 31: 240-255. PMID: 28089890, PMCID: PMC5713901, DOI: 10.1016/j.ccell.2016.12.004.Peer-Reviewed Original ResearchConceptsSingle chromosome gainsSingle extra chromosomeEffects of aneuploidyHallmarks of cancerEvolutionary flexibilityFitness defectsEuploid cellsTumor suppressorExtra chromosomeEuploid counterpartsOncogenic pathwaysProlonged growthChromosomal alterationsCancer developmentCell linesTrisomic cellsImproved fitnessAneuploidyTrisomic cell lineCellsChromosomesSuppressorAdditional chromosomal alterationsGrowthTumorigenesis
2011
Aneuploidy Drives Genomic Instability in Yeast
Sheltzer J, Blank H, Pfau S, Tange Y, George B, Humpton T, Brito I, Hiraoka Y, Niwa O, Amon A. Aneuploidy Drives Genomic Instability in Yeast. Science 2011, 333: 1026-1030. PMID: 21852501, PMCID: PMC3278960, DOI: 10.1126/science.1206412.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyChromosome SegregationChromosomes, FungalDNA DamageDNA RepairDNA ReplicationDNA, FungalGenome, FungalGenomic InstabilityMutagenesisMutationNeoplasmsPhenotypeRad52 DNA Repair and Recombination ProteinRecombination, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsConceptsGenomic instabilityMitotic recombinationDefective DNA damage repairEffects of aneuploidyDNA damage repairCellular fitnessFission yeastGenomic stabilitySingle chromosomeEnhanced proliferative capacityChromosome lossDamage repairExtra copiesYeastGenetic alterationsProliferative capacityAneuploidyMost strainsMalignant growthRecombinationChromosomesTumorigenesisFitnessCopiesGrowth