2024
Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca
Hamchand R, Wang K, Song D, Palm N, Crawford J. Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca. Nature Communications 2024, 15: 8902. PMID: 39406708, PMCID: PMC11480411, DOI: 10.1038/s41467-024-53185-6.Peer-Reviewed Original ResearchConceptsK. oxytocaGeneral carbohydrate metabolismVirulence factor productionPLP-dependent enzymesAssociated with gutEnterobactin biosynthesisAutoinducer signalBacterial virulenceKlebsiella oxytocaSpecific carbohydratesHost immune responseCarbohydrate metabolismAutoinducerMolecular signalsVirulenceHistamine receptor H4BiosynthesisHost signalAcquisition responsesProtease inhibitorsPathwayHostLung pathologyLung isolationImmune response
2020
Phylogenetic and physiological signals in metazoan fossil biomolecules
Wiemann J, Crawford JM, Briggs DEG. Phylogenetic and physiological signals in metazoan fossil biomolecules. Science Advances 2020, 6: eaba6883. PMID: 32832604, PMCID: PMC7439315, DOI: 10.1126/sciadv.aba6883.Peer-Reviewed Original ResearchConceptsEvolutionary historyPhylogenetic informationMetazoan relationshipsMolecular signalsAnimal formsRelative abundanceDifferent tissue typesDeep timeLipoxidation productsTissue typesMetazoan fossilsMolecular compositionMolecular heterogeneityProteinBiological signalsFossil organic matterLipidsPowerful toolSugarsAbundanceLipoxidationGlycoxidationFossilsOrganic matterFossilization