2021
Escherichia coli small molecule metabolism at the host–microorganism interface
Gatsios A, Kim CS, Crawford JM. Escherichia coli small molecule metabolism at the host–microorganism interface. Nature Chemical Biology 2021, 17: 1016-1026. PMID: 34552219, PMCID: PMC8675634, DOI: 10.1038/s41589-021-00807-5.Peer-Reviewed Original ResearchConceptsSmall molecule metabolismE. coliHost-bacteria interfaceModel organismsHost-bacterial interactionsChemical arsenalMolecule metabolismEscherichia coliHuman microbiotaColiSmall molecule chemistryMetabolismCommon componentSignalingOrganismsBiologyDisease modulationCommensalEscherichiaHostPathogenic roleRoleMicrobiotaMembers
2020
Characterization of Autoinducer‑3 Structure and Biosynthesis in E. coli
Kim CS, Gatsios A, Cuesta S, Lam YC, Wei Z, Chen H, Russell RM, Shine EE, Wang R, Wyche TP, Piizzi G, Flavell RA, Palm NW, Sperandio V, Crawford JM. Characterization of Autoinducer‑3 Structure and Biosynthesis in E. coli. ACS Central Science 2020, 6: 197-206. PMID: 32123737, PMCID: PMC7047286, DOI: 10.1021/acscentsci.9b01076.Peer-Reviewed Original ResearchAutoinducer-3Population-level phenotypesDiverse biological rolesGram-positive bacterial pathogensPrimary human tissuesModel organismsQuorum sensingMolecular foundationBiological roleCommon inhabitantsVariety of GramHuman microbiotaVirulence genesBacterial pathogensE. coliBiochemical originBiosynthesisHuman tissuesUnknown structureSynthetase reactionGenesOrganismsBiologyMetabolitesEnterohemorrhagic