β‑Lactam Biotransformations Activate Innate Immunity
Oh J, Patel J, Park HB, Crawford JM. β‑Lactam Biotransformations Activate Innate Immunity. The Journal Of Organic Chemistry 2018, 83: 7173-7179. PMID: 29616809, DOI: 10.1021/acs.joc.8b00241.Peer-Reviewed Original ResearchConceptsHuman microbiota compositionImmune responseImmune functionMicrobiota compositionInnate immunityBroad immunomodulatory mechanismPatient's immune responseClinical trial studyCommon resistance determinantsMicrobiome-dependent mannerImmunomodulatory mechanismsNF-κBTrial studyBacterial infectionsImmunomodulatory interactionsMinimal long-term impactAntibioticsΒ-lactamaseAmoxicillinHuman leukemic monocytesLeukemic monocytesResistance determinantsBiotransformation productsImmunityMolecular mechanisms