2021
Molecules from the Microbiome
Shine EE, Crawford JM. Molecules from the Microbiome. Annual Review Of Biochemistry 2021, 90: 1-27. PMID: 33770448, DOI: 10.1146/annurev-biochem-080320-115307.Peer-Reviewed Original ResearchConceptsHuman microbiomeSpecific microbial moleculesSmall moleculesSecond genomeEcological nichesSpecies compositionGenetic capacityInteraction networksMicrobial moleculesMicrobiome editingBiochemical complexitySynthetic biologyMolecular mechanismsHuman cellsImmune system developmentChemical biologyFunctional interactionMicrobiomeDetailed mechanistic studiesBiologyHost responseMechanistic studiesGenomeMoleculesMicrobes
2019
Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior
Lozano GL, Bravo JI, Diago M, Park HB, Hurley A, Peterson SB, Stabb EV, Crawford JM, Broderick NA, Handelsman J. Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior. MBio 2019, 10: 10.1128/mbio.02846-18. PMID: 30837345, PMCID: PMC6401489, DOI: 10.1128/mbio.02846-18.Peer-Reviewed Original ResearchConceptsGenetic dissectionModel communitiesCommunity-level interactionsMicrobial community behaviorRhizosphere microbiomeModel microbiomeMicrobiome assemblyEmergent propertiesHistory of biologyMicrobial communitiesMammalian gutRobust biofilmsDominant phylaGene expressionBiochemical toolsRhizosphereCommunity interactionsNovel familyHitchhikersMicrobiomeFlavobacteriumModel systemCommunity behaviorPseudomonasAgricultural productivity
2018
Discovering antibiotics from the global microbiome
Lam YC, Crawford JM. Discovering antibiotics from the global microbiome. Nature Microbiology 2018, 3: 392-393. PMID: 29588534, DOI: 10.1038/s41564-018-0135-5.Peer-Reviewed Original Research
2017
Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior
Fischer C, Trautman EP, Crawford JM, Stabb EV, Handelsman J, Broderick NA. Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior. ELife 2017, 6: e18855. PMID: 28068220, PMCID: PMC5222558, DOI: 10.7554/elife.18855.Peer-Reviewed Original ResearchConceptsMicrobial communitiesContext-dependent fitness benefitsMulti-species microbial communitiesMicrobial community influencesMicrobe-microbe interactionsEgg-laying preferenceInter-species interactionsEgg-laying behaviorHost-microbiome interactionsDistinct volatile profileMicrobiome membersFitness benefitsMetabolite exchangePopulation declineDrosophila behaviorMolecular mechanismsOlfactory receptorsMetabolic derivativesEthanol catabolismAnimal behaviorCurrent understandingMicrobiomeOr42bIndividual membersDrosophila