2019
Bacterial Analogs of Plant Tetrahydropyridine Alkaloids Mediate Microbial Interactions in a Rhizosphere Model System
Lozano GL, Park HB, Bravo JI, Armstrong EA, Denu JM, Stabb EV, Broderick NA, Crawford JM, Handelsman J. Bacterial Analogs of Plant Tetrahydropyridine Alkaloids Mediate Microbial Interactions in a Rhizosphere Model System. Applied And Environmental Microbiology 2019, 85: e03058-18. PMID: 30877115, PMCID: PMC6498172, DOI: 10.1128/aem.03058-18.Peer-Reviewed Original ResearchConceptsRhizosphere communitiesGene clusterUncharacterized biosynthetic gene clustersMicrobiome of plantsRhizosphere microbial communitiesBiosynthetic gene clusterIndividual species' behaviorSecretion of antibioticsRhizosphere model systemPlant photosynthatesGenetic screenInterbacterial competitionConvergent evolutionRhizosphere bacteriaMicrobial interactionsRhizosphere inhabitantsCommunity compositionMicrobial communitiesRepertoire of antibioticsDiverse consortiumSoybean rhizosphereSelective environmentGenetic basisMultidimensional nuclear magnetic resonanceSoybean roots
2015
Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways
Engel P, Vizcaino MI, Crawford JM. Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways. Applied And Environmental Microbiology 2015, 81: 1502-1512. PMID: 25527542, PMCID: PMC4309719, DOI: 10.1128/aem.03283-14.Peer-Reviewed Original ResearchConceptsNonribosomal peptide synthetaseBiosynthetic pathwayBacterial symbiontsGut symbiontsSecondary metabolitesEukaryotic cellsGenomic islandsBacterial gut symbiontDiverse symbiotic associationsDivergent variantsDNA damagePolyketide synthase pathwayE. coliComparative metabolomic analysisRelated secondary metabolitesPathway-dependent mannerSymbiotic associationGene clusterMicrobial interactionsBiosynthesis pathwayDistinct hostsPeptide synthetaseMammalian gutHoney beesSymbionts