2019
Bacterial Analogs of Plant Tetrahydropyridine Alkaloids Mediate Microbial Interactions in a Rhizosphere Model System
Lozano GL, Park HB, Bravo JI, Armstrong EA, Denu JM, Stabb EV, Broderick NA, Crawford JM, Handelsman J. Bacterial Analogs of Plant Tetrahydropyridine Alkaloids Mediate Microbial Interactions in a Rhizosphere Model System. Applied And Environmental Microbiology 2019, 85: e03058-18. PMID: 30877115, PMCID: PMC6498172, DOI: 10.1128/aem.03058-18.Peer-Reviewed Original ResearchConceptsRhizosphere communitiesGene clusterUncharacterized biosynthetic gene clustersMicrobiome of plantsRhizosphere microbial communitiesBiosynthetic gene clusterIndividual species' behaviorSecretion of antibioticsRhizosphere model systemPlant photosynthatesGenetic screenInterbacterial competitionConvergent evolutionRhizosphere bacteriaMicrobial interactionsRhizosphere inhabitantsCommunity compositionMicrobial communitiesRepertoire of antibioticsDiverse consortiumSoybean rhizosphereSelective environmentGenetic basisMultidimensional nuclear magnetic resonanceSoybean rootsIntroducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior
Lozano GL, Bravo JI, Diago M, Park HB, Hurley A, Peterson SB, Stabb EV, Crawford JM, Broderick NA, Handelsman J. Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior. MBio 2019, 10: 10.1128/mbio.02846-18. PMID: 30837345, PMCID: PMC6401489, DOI: 10.1128/mbio.02846-18.Peer-Reviewed Original ResearchConceptsGenetic dissectionModel communitiesCommunity-level interactionsMicrobial community behaviorRhizosphere microbiomeModel microbiomeMicrobiome assemblyEmergent propertiesHistory of biologyMicrobial communitiesMammalian gutRobust biofilmsDominant phylaGene expressionBiochemical toolsRhizosphereCommunity interactionsNovel familyHitchhikersMicrobiomeFlavobacteriumModel systemCommunity behaviorPseudomonasAgricultural productivity
2017
Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior
Fischer C, Trautman EP, Crawford JM, Stabb EV, Handelsman J, Broderick NA. Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior. ELife 2017, 6: e18855. PMID: 28068220, PMCID: PMC5222558, DOI: 10.7554/elife.18855.Peer-Reviewed Original ResearchConceptsMicrobial communitiesContext-dependent fitness benefitsMulti-species microbial communitiesMicrobial community influencesMicrobe-microbe interactionsEgg-laying preferenceInter-species interactionsEgg-laying behaviorHost-microbiome interactionsDistinct volatile profileMicrobiome membersFitness benefitsMetabolite exchangePopulation declineDrosophila behaviorMolecular mechanismsOlfactory receptorsMetabolic derivativesEthanol catabolismAnimal behaviorCurrent understandingMicrobiomeOr42bIndividual membersDrosophila