Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial
Bots ML, Visseren FL, Evans GW, Riley WA, Revkin JH, Tegeler CH, Shear CL, Duggan WT, Vicari RM, Grobbee DE, Kastelein JJ, Investigators F. Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. The Lancet 2007, 370: 153-160. PMID: 17630038, DOI: 10.1016/s0140-6736(07)61088-5.Peer-Reviewed Original ResearchConceptsIntima-media thicknessMaximum intima-media thicknessCarotid intima-media thicknessDouble-blind trialSystolic blood pressureCombined-treatment groupMixed dyslipidaemiaCholesteryl ester transfer proteinHDL cholesterolLipoprotein cholesterolBlood pressureLDL cholesterolCarotid segmentsHigh low-density lipoprotein cholesterolLow high-density lipoprotein cholesterolMaximum carotid intima-media thicknessHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolCarotid atherosclerosis progressionDose of treatmentYearly rateEster transfer proteinDose titrationPrimary endpointAtherosclerosis progression