2016
Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015
Appiah GD, Chaves SS, Kirley PD, Miller L, Meek J, Anderson E, Oni O, Ryan P, Eckel S, Lynfield R, Bargsten M, Zansky SM, Bennett N, Lung K, McDonald-Hamm C, Thomas A, Brady D, Lindegren ML, Schaffner W, Hill M, Garg S, Fry AM, Campbell AP. Increased Antiviral Treatment Among Hospitalized Children and Adults With Laboratory-Confirmed Influenza, 2010–2015. Clinical Infectious Diseases 2016, 64: 364-367. PMID: 28013261, PMCID: PMC5480237, DOI: 10.1093/cid/ciw745.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntiviral AgentsChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanLength of StayLongitudinal StudiesMaleMiddle AgedOseltamivirPandemicsProspective StudiesRetrospective StudiesSeasonsUnited StatesYoung AdultSurvey of influenza and other respiratory viruses diagnostic testing in US hospitals, 2012–2013
Su S, Fry AM, Kirley PD, Aragon D, Yousey‐Hindes K, Meek J, Openo K, Oni O, Sharangpani R, Morin C, Hollick G, Lung K, Laidler M, Lindegren ML, Schaffner W, Atkinson A, Chaves SS. Survey of influenza and other respiratory viruses diagnostic testing in US hospitals, 2012–2013. Influenza And Other Respiratory Viruses 2016, 10: 86-90. PMID: 26505742, PMCID: PMC4746564, DOI: 10.1111/irv.12355.Peer-Reviewed Original ResearchConceptsInfluenza Hospitalization Surveillance NetworkRespiratory virusesAvailable rapid influenza diagnostic testsRapid influenza diagnostic testsInfluenza diagnostic testsOptimal clinical managementInfection control practitionersSurvey of hospitalsDetection of influenzaSurveillance networkInfluenza infectionClinical managementCatchment populationStandardized questionnaireUS hospitalsHospitalDiagnostic testingInfluenzaLaboratory capacityTelephone interviewsDiagnostic testsMolecular diagnostic assaysInsensitive assayControl practitionersDiagnostic practice
2015
Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008
Garg S, Jain S, Dawood FS, Jhung M, Pérez A, D’Mello T, Reingold A, Gershman K, Meek J, Arnold KE, Farley MM, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett N, Thomas A, Schaffner W, Finelli L. Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008. BMC Infectious Diseases 2015, 15: 369. PMID: 26307108, PMCID: PMC4550040, DOI: 10.1186/s12879-015-1004-y.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionSeasonal influenza virus infectionICD-9-CM codesCertain underlying conditionsEmerging Infections ProgramCare unit admissionLaboratory-confirmed influenzaInfluenza virus infectionCause of deathCXR infiltrateUnit admissionICU admissionOlder patientsMechanical ventilationMultivariable analysisUnderlying conditionInfections ProgramChest radiographsVirus infectionPneumoniaSummary diagnosisInfectious diseasesInfluenzaPatientsAdultsObesity not associated with severity among hospitalized adults with seasonal influenza virus infection
Braun ES, Crawford FW, Desai MM, Meek J, Kirley PD, Miller L, Anderson EJ, Oni O, Ryan P, Lynfield R, Bargsten M, Bennett NM, Lung KL, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Chaves SS. Obesity not associated with severity among hospitalized adults with seasonal influenza virus infection. Infection 2015, 43: 569-575. PMID: 26148927, DOI: 10.1007/s15010-015-0802-x.Peer-Reviewed Original ResearchConceptsSeasonal influenza virus infectionMultivariate logistic regression modelSeasonal influenza severityLaboratory-confirmed influenzaRisk of pneumoniaInfluenza virus infectionLogistic regression modelsHospitalized adultsICU admissionObese patientsSevere obesityInfluenza severityArtificial ventilationVirus infectionWeight categoriesObesityPneumoniaSeverityRegression modelsAdultsUnderweightPatientsAdmissionInfectionInfluenzaDoes Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States
Arriola C, Anderson E, Baumbach J, Bennett N, Bohm S, Hill M, Lindegren M, Lung K, Meek J, Mermel E, Miller L, Monroe M, Morin C, Oni O, Reingold A, Schaffner W, Thomas A, Zansky S, Finelli L, Chaves S. Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012−2013 Season in the United States. The Journal Of Infectious Diseases 2015, 212: 1200-1208. PMID: 25821227, PMCID: PMC4683374, DOI: 10.1093/infdis/jiv200.Peer-Reviewed Original ResearchConceptsInfluenza vaccinationInfluenza severityDisease severityIntensive care unit admissionMultivariable logistic regression modelSevere influenza outcomesCare unit admissionLaboratory-confirmed influenzaMultivariable logistic regressionDiagnosis of pneumoniaLogistic regression modelsUnit admissionICU lengthVaccine effectivenessInfluenza seasonParametric survival modelsInfluenza outcomesVaccinated personsVaccinationPropensity scoreLogistic regressionOlder adultsPredominant strainSeverityInfluenzaStatin Treatment and Mortality: Propensity Score-Matched Analyses of 2007–2008 and 2009–2010 Laboratory-Confirmed Influenza Hospitalizations
Laidler M, Thomas A, Baumbach J, Kirley P, Meek J, Aragon D, Morin C, Ryan P, Schaffner W, Zansky S, Chaves S. Statin Treatment and Mortality: Propensity Score-Matched Analyses of 2007–2008 and 2009–2010 Laboratory-Confirmed Influenza Hospitalizations. Open Forum Infectious Diseases 2015, 2: ofv028. PMID: 26034777, PMCID: PMC4438907, DOI: 10.1093/ofid/ofv028.Peer-Reviewed Original ResearchPropensity score-matched analysisStatin treatmentAdjunct treatmentInfluenza virus infectionHost inflammatory responseAnnual influenza epidemicsInfluenza hospitalizationsInfluenza seasonSubstantial morbidityHospitalized cohortCox regressionImmunomodulatory agentsInflammatory responseVirus infectionProtective effectInfluenza epidemicsSurveillance dataMortalityUnmeasured confoundersStatinsDeathTreatmentVaccine productionInfluenzaPandemic
2014
1341The benefit of early influenza antiviral treatment of pregnant women hospitalized with laboratory-confirmed influenza
Oboho I, Reed C, Leon M, Rothrock G, Aragon D, Meek J, Farley M, Ryan P, Peters S, Lynfield R, Morin C, Bargsten M, Zansky S, Fowler B, Thomas A, Mermel E, Lindegren M, Risk I, Finelli L, Chaves S. 1341The benefit of early influenza antiviral treatment of pregnant women hospitalized with laboratory-confirmed influenza. Open Forum Infectious Diseases 2014, 1: s58-s58. PMCID: PMC5781581, DOI: 10.1093/ofid/ofu051.158.Peer-Reviewed Original Research
2013
Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites
Thompson M, Sokolow L, Almendares O, Openo K, Farley M, Meek J, Ray J, Kirley P, Reingold A, Aragon D, Hancock E, Baumbach J, Schaffner W, Thomas A, Lynfield R, Ryan P, Monroe M, Cheng P, Fry A, Shay D. Effectiveness of Nonadjuvanted Monovalent Influenza A(H1N1)pdm09 Vaccines for Preventing Reverse Transcription Polymerase Chain Reaction–Confirmed Pandemic Influenza Hospitalizations: Case-Control Study of Children and Adults at 10 US Influenza Surveillance Network Sites. Clinical Infectious Diseases 2013, 57: 1587-1592. PMID: 23956169, PMCID: PMC7314184, DOI: 10.1093/cid/cit551.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed pandemic influenzaCommunity-matched controlsCase-control studyReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionInfluenza hospitalizationsMonovalent influenzaPandemic influenzaSingle dosePolymerase chain reactionVirus infectionInfluenzaChain reactionHospitalizationVaccinePatientsInfectionDose
2012
Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic
Garg S, Chaves SS, Pérez A, D'Mello T, Gershman K, Meek J, Yousey-Hindes K, Arnold KE, Farley MM, Tengelsen L, Ryan P, Sharangpani R, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Fowler B, Bradley K, Thomas A, Cooper T, Schaffner W, Boulton R, Finelli L, Fry AM. Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic. Clinical Infectious Diseases 2012, 55: e18-e21. PMID: 22543024, DOI: 10.1093/cid/cis442.Peer-Reviewed Original ResearchInfluenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC
Luckhaupt SE, Sweeney MH, Funk R, Calvert GM, Nowell M, D'Mello T, Reingold A, Meek J, Yousey-Hindes K, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Jones T. Influenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 556-562. PMID: 22469504, PMCID: PMC3309704, DOI: 10.3201/eid1804.110337.Peer-Reviewed Original Research
2011
Children With Asthma Hospitalized With Seasonal or Pandemic Influenza, 2003–2009
Dawood F, Kamimoto L, D'Mello T, Reingold A, Gershman K, Meek J, Arnold K, Farley M, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett N, Thomas A, Schaffner W, Kirschke D, Finelli L. Children With Asthma Hospitalized With Seasonal or Pandemic Influenza, 2003–2009. Pediatrics 2011, 128: e27-e32. PMID: 21646257, DOI: 10.1542/peds.2010-3343.Peer-Reviewed Original ResearchConceptsPandemic H1N1 influenzaAdditional medical conditionsAsthmatic childrenClinical courseInfluenza seasonH1N1 influenzaMedical conditionsLaboratory-confirmed influenzaAsthma exacerbationsRespiratory failureAsthma severityMedian ageInfluenza BInfluenza preventionIntensive careSeasonal influenzaMedical historyMedical recordsInfluenza AInfluenza typeAsthmaInfluenzaCare occurSubstantial proportionComplicationsSeasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: a population-based study of hospitalized cases
Creanga A, Kamimoto L, Newsome K, D'Mello T, Jamieson D, Zotti M, Arnold K, Baumbach J, Bennett N, Farley M, Gershman K, Kirschke D, Lynfield R, Meek J, Morin C, Reingold A, Ryan P, Schaffner W, Thomas A, Zansky S, Finelli L, Honein M. Seasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: a population-based study of hospitalized cases. American Journal Of Obstetrics And Gynecology 2011, 204: s38-s45. PMID: 21507375, DOI: 10.1016/j.ajog.2011.02.037.Peer-Reviewed Original ResearchConceptsReproductive-aged womenPandemic influenza A (H1N1) virus infectionInfluenza A Virus InfectionA virus infectionPregnant womenPandemic influenzaVirus infectionExact testEmerging Infections ProgramPandemic influenza casesUnderlying medical conditionsPopulation-based studyPopulation-based dataFisher's exact testInfluenza vaccinationNonpregnant womenAntiviral treatmentSeasonal influenzaInfections ProgramInfluenza casesMedical conditionsPregnancyWomenInfluenzaSignificant proportion
2010
Adult Hospitalizations for Laboratory-Positive Influenza during the 2005–2006 through 2007–2008 Seasons in the United States
Dao C, Kamimoto L, Nowell M, Reingold A, Gershman K, Meek J, Arnold K, Farley M, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock E, Zansky S, Bennett N, Thomas A, Vandermeer M, Kirschke D, Schaffner W, Finelli L. Adult Hospitalizations for Laboratory-Positive Influenza during the 2005–2006 through 2007–2008 Seasons in the United States. The Journal Of Infectious Diseases 2010, 202: 881-888. PMID: 20677944, DOI: 10.1086/655904.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalizationsInfluenza seasonEmerging Infections Program NetworkEmerging Infections Program sitesHospitalization discharge diagnosesInfections Program NetworkInfluenza-associated complicationsRate of hospitalizationLaboratory-positive casesAge-specific ratesTypes/subtypesAdult hospitalizationsHospitalization surveillanceClinical characteristicsInfluenza B.Discharge diagnosisMedical conditionsHospitalizationMetabolic diseasesIncreased circulationInfluenza virusOverall rateInfluenzaPredominant seasonsAgeInfluenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003–2008
Dawood FS, Fiore A, Kamimoto L, Nowell M, Reingold A, Gershman K, Meek J, Hadler J, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Kirschke D, Finelli L. Influenza-Associated Pneumonia in Children Hospitalized With Laboratory-Confirmed Influenza, 2003–2008. The Pediatric Infectious Disease Journal 2010, 29: 585-590. PMID: 20589966, PMCID: PMC5856105, DOI: 10.1097/inf.0b013e3181d411c5.Peer-Reviewed Original ResearchConceptsInfluenza-associated pneumoniaChest radiographsHospitalized childrenIntensive care unit admissionCare unit admissionLaboratory-confirmed influenzaSevere clinical courseInfluenza complicationsUnit admissionRespiratory failureCommon complicationClinical courseInfluenza seasonTreatment strategiesPneumoniaMultivariate analysisNew pneumoniaGreater riskInfluenzaRadiographsAge 6Age 2HospitalizationAsthmaComplications