2014
The Modulating Role of Stress in the Onset and Course of Tourette’s Syndrome
Buse J, Kirschbaum C, Leckman JF, Münchau A, Roessner V. The Modulating Role of Stress in the Onset and Course of Tourette’s Syndrome. Behavior Modification 2014, 38: 184-216. PMID: 24516255, DOI: 10.1177/0145445514522056.Peer-Reviewed Original ResearchMeSH KeywordsHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemStress, PhysiologicalStress, PsychologicalSynaptic TransmissionTourette SyndromeConceptsTourette syndromePsychosocial stressActivation of HPAAdrenal axis activationExacerbation of ticsNoradrenergic neurotransmissionAxis activationHPA axisTic disordersTic exacerbationAberrant markersSyndromeNeurotransmissionModulating roleExacerbationPatientsUnderlying mechanismStrong activationImmunologyActivationCommon occurrenceSubsequent changesDopaminergicAbnormalitiesPathology
2006
Annotation: Tourette syndrome: a relentless drumbeat – driven by misguided brain oscillations
Leckman JF, Vaccarino FM, Kalanithi PS, Rothenberger A. Annotation: Tourette syndrome: a relentless drumbeat – driven by misguided brain oscillations. Journal Of Child Psychology And Psychiatry 2006, 47: 537-550. PMID: 16712630, DOI: 10.1111/j.1469-7610.2006.01620.x.Peer-Reviewed Original ResearchConceptsTourette syndromeNormal central nervous system functionCentral nervous system functionNeural oscillationsAberrant neural oscillationsSuccessful behavioral treatmentNervous system functionMotor actionsSurgical interventionThalamocortical rhythmsElectrophysiological effectsElectrophysiological findingsSensorimotor gatingSensory urgeSynaptic plasticityTic suppressionAmeliorative effectBehavioral treatmentMotor responsePrefrontal cortexAberrant oscillationsCoherent network activityEffective modulatorPrefrontal regionsRecent evidence