2014
Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome
Landeros-Weisenberger A, Mantovani A, Motlagh MG, de Alvarenga PG, Katsovich L, Leckman JF, Lisanby SH. Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome. Brain Stimulation 2014, 8: 574-581. PMID: 25912296, PMCID: PMC4454615, DOI: 10.1016/j.brs.2014.11.015.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationSham repetitive transcranial magnetic stimulationSupplementary motor areaLow-frequency repetitive transcranial magnetic stimulationFrequency repetitive transcranial magnetic stimulationActive repetitive transcranial magnetic stimulationSevere Tourette syndromeTranscranial magnetic stimulationTourette syndromeTic severityMagnetic stimulationDouble-blind sham-controlled trialEfficacy of rTMSOpen-label active treatmentYGTSS total tic scoreAlternative stimulation protocolsDouble-blind trialOpen-label studySham-controlled trialTotal tic scoreActive rTMS treatmentRandomized ShamRTMS treatmentActive treatmentMotor threshold
2011
Biofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions
Hampson M, Scheinost D, Qiu M, Bhawnani J, Lacadie CM, Leckman JF, Constable RT, Papademetris X. Biofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions. Brain Connectivity 2011, 1: 91-98. PMID: 22432958, PMCID: PMC3621512, DOI: 10.1089/brain.2011.0002.Peer-Reviewed Original ResearchConceptsSupplementary motor areaReal-time functional magnetic resonanceFunctional connectivityTourette syndromeFunctional magnetic resonanceMotor areaSubcortical regionsBiofeedback sessionsState functional connectivityTic symptomsMagnetic resonance imaging dataHealthy subjectsTS patientsMagnetic resonanceBrain areasBiofeedbackFunctional magnetic resonance imaging (fMRI) dataFurther studiesSignificant increaseAberrant dynamicsSubjectsRecent studiesImaging dataSessionsPatients
2008
Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements
Hampson M, Tokoglu F, King RA, Constable RT, Leckman JF. Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements. Biological Psychiatry 2008, 65: 594-599. PMID: 19111281, PMCID: PMC2679868, DOI: 10.1016/j.biopsych.2008.11.012.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansIntentionMagnetic Resonance ImagingMaleMotor CortexMovementTic DisordersTourette SyndromeConceptsMotor cortexSupplementary motor areaControl subjectsBrain areasMotor ticsTic disordersTic movementsMotor areaTic-like movementsHealthy control subjectsChronic tic disorderNormal control subjectsChronic motor ticsNovel intervention strategiesFunctional neuroimaging studiesTic executionSevere ticsIntentional movementPatient's ticsMotor regionsPremonitory urgesBrain activity patternsAdult subjectsTic generationCortex
2007
Repetitive Transcranial Magnetic Stimulation of the Supplementary Motor Area in the treatment of Tourette Syndrome: Report of two cases
Mantovani A, Leckman JF, Grantz H, King RA, Sporn AL, Lisanby SH. Repetitive Transcranial Magnetic Stimulation of the Supplementary Motor Area in the treatment of Tourette Syndrome: Report of two cases. Clinical Neurophysiology 2007, 118: 2314-2315. PMID: 17709291, DOI: 10.1016/j.clinph.2007.07.011.Peer-Reviewed Original Research
1993
Premonitory urges in Tourette's syndrome
Leckman JF, Walker DE, Cohen DJ. Premonitory urges in Tourette's syndrome. American Journal Of Psychiatry 1993, 150: 98-102. PMID: 8417589, DOI: 10.1176/ajp.150.1.98.Peer-Reviewed Original ResearchConceptsTic disordersPremonitory urgesTourette syndromeYale Global Tic Severity ScaleHyperkinetic movement disordersCross-sectional studyTic Severity ScaleVoluntary responseMidline abdomenTic symptomsPhonic ticsMovement disordersEpidemiological studiesSeverity ScaleCase findingTic severityPrevalence dataAdult subjectsBrain regionsSyndromeTic behaviorsInvoluntary motorFeeling of reliefDisordersAnatomical regions