2012
Systematic review: Pharmacological treatment of tic disorders – Efficacy of antipsychotic and alpha-2 adrenergic agonist agents
Weisman H, Qureshi IA, Leckman JF, Scahill L, Bloch MH. Systematic review: Pharmacological treatment of tic disorders – Efficacy of antipsychotic and alpha-2 adrenergic agonist agents. Neuroscience & Biobehavioral Reviews 2012, 37: 1162-1171. PMID: 23099282, PMCID: PMC3674207, DOI: 10.1016/j.neubiorev.2012.09.008.Peer-Reviewed Original Research
1988
Fluoxetine treatment of obsessions and compulsions in patients with Tourette's syndrome
Riddle MA, Leckman JF, Hardin MT, Anderson GM, Cohen DJ. Fluoxetine treatment of obsessions and compulsions in patients with Tourette's syndrome. American Journal Of Psychiatry 1988, 145: 1173a-1174. PMID: 3046386, DOI: 10.1176/ajp.145.9.1173a.Peer-Reviewed Original ResearchAdultClinical Trials as TopicFluoxetineHumansMaleObsessive-Compulsive DisorderPropylaminesTourette Syndrome
1985
Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective.
Leckman J, Detlor J, Harcherik D, Ort S, Shaywitz B, Cohen D. Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective. Neurology 1985, 35: 343-51. PMID: 3883235, DOI: 10.1212/wnl.35.3.343.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBehaviorChildClinical Trials as TopicClonidineDisability EvaluationFemaleHumansMalePatient ComplianceSelf ConceptTime FactorsTourette SyndromeConceptsTourette syndromeGilles de la Tourette's syndromePlacebo-controlled trialDouble-blind studyLong-term treatmentSerious side effectsLa Tourette's syndromeUnequivocal respondersPhonic ticsClonidineSide effectsSyndromeDrug efficacyEquivocal responseClinical perspectivePatientsEfficacyBehavior problemsSignificant improvementRespondersTrialsWeeks
1982
Clonidine in the treatment of Tourette syndrome: a review of data.
Leckman JF, Cohen DJ, Detlor J, Young JG, Harcherik D, Shaywitz BA. Clonidine in the treatment of Tourette syndrome: a review of data. Advances In Neurology 1982, 35: 391-401. PMID: 6756089.Peer-Reviewed Original ResearchConceptsTS patientsLong-term symptomatic improvementPathophysiology of TSDouble-blind trialEfficacy of clonidineMinority of patientsGrowth hormone releasePrimary pathogenic importanceMinimal side effectsSymptomatic improvementBlood pressureProfile of responseNoradrenergic mechanismsMHPG levelsTherapeutic responseHormone releaseClonidinePathogenic importanceAcute dosesSide effectsTourette syndromeBehavioral symptomsPharmacologic investigationsNeurochemical systemsPatients
1971
Pentylenetetrazol in the Treatment of Geriatric Patients with Disturbed Memory Function
LECKMAN J, ANANTH JV, BAN TA, LEHMANN HE. Pentylenetetrazol in the Treatment of Geriatric Patients with Disturbed Memory Function. The Journal Of Clinical Pharmacology 1971, 11: 301-303. PMID: 4932747, DOI: 10.1177/009127007101100409.Peer-Reviewed Original Research