2020
Effects of the Global Coronavirus Disease-2019 Pandemic on Early Childhood Development: Short- and Long-Term Risks and Mitigating Program and Policy Actions
Yoshikawa H, Wuermli AJ, Britto PR, Dreyer B, Leckman JF, Lye SJ, Ponguta LA, Richter LM, Stein A. Effects of the Global Coronavirus Disease-2019 Pandemic on Early Childhood Development: Short- and Long-Term Risks and Mitigating Program and Policy Actions. The Journal Of Pediatrics 2020, 223: 188-193. PMID: 32439312, PMCID: PMC7234941, DOI: 10.1016/j.jpeds.2020.05.020.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusChildChild DevelopmentChild MortalityChild WelfareCommunicable Disease ControlCoronavirus InfectionsCOVID-19CrowdingEconomicsFemaleGlobal HealthHealth BehaviorHumansMaternal HealthMaternal MortalityMental HealthPandemicsParentsPneumonia, ViralPregnancyPrenatal Exposure Delayed EffectsResource AllocationSARS-CoV-2Stress, Psychological
2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2017
What Are the Transgenerational Consequences of Maternal Childhood Adversity and Maternal Stress During Pregnancy?
Leckman JF. What Are the Transgenerational Consequences of Maternal Childhood Adversity and Maternal Stress During Pregnancy? Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 56: 914-915. PMID: 29096770, DOI: 10.1016/j.jaac.2017.09.421.Peer-Reviewed Original Research
2016
Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder
Fernandez TV, Leckman JF. Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. JAMA Psychiatry 2016, 73: 1117-1118. PMID: 27706471, PMCID: PMC5180419, DOI: 10.1001/jamapsychiatry.2016.2092.Peer-Reviewed Original Research
2015
Maternal History of Autoimmune Disease and Later Development of Tourette Syndrome in Offspring
Dalsgaard S, Waltoft BL, Leckman JF, Mortensen PB. Maternal History of Autoimmune Disease and Later Development of Tourette Syndrome in Offspring. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 495-501.e1. PMID: 26004665, DOI: 10.1016/j.jaac.2015.03.008.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratioIncidence rate ratiosMaternal autoimmune diseaseRisk of TSAutoimmune diseasesTourette syndromeMaternal historyNational Danish health registersNationwide prospective cohort studyDanish health registersPrior autoimmune diseaseProspective cohort studyParental psychiatric diagnosisDiagnosis of TSCohort studyHealth registersPerson yearsPrior diagnosisNeuroimmunological disordersIncidence rateTS diagnosisPsychiatric diagnosisPossible associationPoisson regressionPaternal age
2011
Variations in Maternal Behavior—Oxytocin and Reward Pathways—Peripheral Measures Matter?!
Leckman JF. Variations in Maternal Behavior—Oxytocin and Reward Pathways—Peripheral Measures Matter?! Neuropsychopharmacology 2011, 36: 2587-2588. PMID: 22071897, PMCID: PMC3230502, DOI: 10.1038/npp.2011.201.Peer-Reviewed Original Research
2010
Adverse Effects of Heavy Prenatal Maternal Smoking on Attentional Control in Children With ADHD
Motlagh MG, Sukhodolsky DG, Landeros-Weisenberger A, Katsovich L, Thompson N, Scahill L, King RA, Peterson BS, Schultz RT, Leckman JF. Adverse Effects of Heavy Prenatal Maternal Smoking on Attentional Control in Children With ADHD. Journal Of Attention Disorders 2010, 15: 593-603. PMID: 20616372, PMCID: PMC3974616, DOI: 10.1177/1087054710374576.Peer-Reviewed Original ResearchConceptsConnors' Continuous Performance TestContinuous Performance TestAttentional controlPrenatal maternal smokingStroop Color-Word Interference TestColor-Word Interference TestMaternal smokingVisual-Motor Integration TestRisk factorsBeery Visual-Motor Integration TestReaction time variabilityVisual-motor integrationSlower reaction timesDevelopment of ADHDFine motor coordinationNeuropsychological batteryPurdue Pegboard TestHeavy maternal smokingMaternal cigarette smokingPerinatal risk factorsMaternal psychosocial stressMotor inhibitionNeurobiological basisNeuropsychological deficitsADHDSevere psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome
Motlagh MG, Katsovich L, Thompson N, Lin H, Kim YS, Scahill L, Lombroso PJ, King RA, Peterson BS, Leckman JF. Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome. European Child & Adolescent Psychiatry 2010, 19: 755-764. PMID: 20532931, PMCID: PMC3932440, DOI: 10.1007/s00787-010-0115-7.Peer-Reviewed Original ResearchConceptsHeavy maternal smokingPerinatal risk factorsAttention-deficit/hyperactivity disorderSevere psychosocial stressRisk factorsMaternal smokingTourette syndromePsychosocial stressUnaffected control childrenControl childrenHeavy cigarette smokingHigh-risk populationStatistical significanceDiagnosis of ADHDComorbid Tourette's syndromeHigh rateMothers of childrenMaternal report dataHeavy smokingPerinatal historyCigarette smokingOdds ratioPsychiatric assessmentSmokingStandardized questionnaire
2007
Nurturing resilient children
Leckman JF, Mayes LC. Nurturing resilient children. Journal Of Child Psychology And Psychiatry 2007, 48: 221-223. PMID: 17355396, DOI: 10.1111/j.1469-7610.2007.01743.x.Peer-Reviewed Original Research
2003
Expression of BEN, a member of TFII-I family of transcription factors, during mouse pre- and postimplantation development
Bayarsaihan D, Bitchevaia N, Enkhmandakh B, Tussie-Luna MI, Leckman JF, Roy A, Ruddle F. Expression of BEN, a member of TFII-I family of transcription factors, during mouse pre- and postimplantation development. Gene Expression Patterns 2003, 3: 579-589. PMID: 12971990, DOI: 10.1016/s1567-133x(03)00118-2.Peer-Reviewed Original ResearchConceptsTFII-I familyTranscription factorsPostimplantation developmentEarly gastrulation stagesExtensive expression patternMouse preTwo-cell stageGastrulation stageEarly blastocyst stageRepeat domainNuclear localizationExpression patternsTissue developmentBlastocyst stageMost tissuesCytoplasmExpressionExtensive expression
2002
CLINICAL CHARACTERISTICS OF TOURETTE SYNDROME PROBANDS AND RELATIVES’ RISKS
Kano Y, Leckman JF, Pauls DL. CLINICAL CHARACTERISTICS OF TOURETTE SYNDROME PROBANDS AND RELATIVES’ RISKS. Journal Of The American Academy Of Child & Adolescent Psychiatry 2002, 41: 1148-1149. PMID: 12364837, DOI: 10.1097/00004583-200210000-00005.Peer-Reviewed Original Research