2016
N-Acetylcysteine in the Treatment of Pediatric Tourette Syndrome: Randomized, Double-Blind, Placebo-Controlled Add-On Trial
Bloch MH, Panza KE, Yaffa A, Alvarenga PG, Jakubovski E, Mulqueen JM, Landeros-Weisenberger A, Leckman JF. N-Acetylcysteine in the Treatment of Pediatric Tourette Syndrome: Randomized, Double-Blind, Placebo-Controlled Add-On Trial. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 327-334. PMID: 27027204, PMCID: PMC6445198, DOI: 10.1089/cap.2015.0109.Peer-Reviewed Original ResearchConceptsBenefit of NACEfficacy of NACYale Global Tic Severity ScaleAttention-deficit/hyperactivity disorderObsessive-compulsive disorderTourette syndromeN-acetylcysteineObsessive-compulsive spectrum disordersSide effectsRecent placebo-controlled trialPediatric Tourette syndromePlacebo-controlled trialCurrent pharmacological treatmentsTreatment of ticsTotal tic scoreSeverity of ticsSubstantial side effectsTic Severity ScaleYears of ageMinimal side effectsPediatric TSPrimary outcomeSecondary outcomesGlutamatergic systemPharmacological treatment
1997
FUTURE THERAPIES OF TOURETTE SYNDROME * *Portions of this article have previously appeared in Chappell PB, Leckman JF, Riddle MA: The pharmacologic treatment of tic disorders. Child Adolesc Psychiatr Clin North Am. 4:197, 1995.
Chappell PB, Scahill LD, Leckman JF. FUTURE THERAPIES OF TOURETTE SYNDROME * *Portions of this article have previously appeared in Chappell PB, Leckman JF, Riddle MA: The pharmacologic treatment of tic disorders. Child Adolesc Psychiatr Clin North Am. 4:197, 1995. Neurologic Clinics 1997, 15: 429-450. PMID: 9115473, DOI: 10.1016/s0733-8619(05)70324-8.Peer-Reviewed Original ResearchConceptsTourette syndromeNew atypical antipsychotic medicationsCorticotropin-releasing factor antagonistAmino acid neurotransmitter systemsUnacceptable side effect profileAvailable pharmacologic therapiesNewer atypical antipsychoticsTreatment of ticsSide effect profileSubgroup of patientsAtypical antipsychotic medicationsTourette syndrome patientsLong-term courseReceptor affinity profileNonpharmacologic interventionsPharmacologic therapyPharmacologic treatmentAtypical antipsychoticsEffect profileAntipsychotic medicationTic disordersNeurotransmitter systemsSyndrome patientsFactor antagonistsSet of symptomsFluoxetine Has No Marked Effect on Tic Symptoms in Patients with Tourette's Syndrome: A Double-Blind Placebo-Controlled Study
Scahill L, Riddle MA, King RA, Hardin MT, Rasmusson A, Makuch RW, Leckman JF. Fluoxetine Has No Marked Effect on Tic Symptoms in Patients with Tourette's Syndrome: A Double-Blind Placebo-Controlled Study. Journal Of Child And Adolescent Psychopharmacology 1997, 7: 75-85. PMID: 9334893, DOI: 10.1089/cap.1997.7.75.Peer-Reviewed Original ResearchConceptsTourette syndromeObsessive-compulsive symptomsObsessive-compulsive disorderPlacebo-controlled crossover trialTreatment of ticsWeeks of treatmentEfficacy of fluoxetineFluoxetine monotherapyFluoxetine treatmentCrossover trialObsessive-compulsive featuresAdditional subjectsFluoxetineSymptomsSignificant reductionSyndromeTreatmentSubjectsCrossover analysisMonotherapyPatientsMarked effectTrialsWeeks