2022
A Family Study of Gilles de la Tourette Syndrome
Pauls D, Raymond C, Stevenson J, Leckman J. A Family Study of Gilles de la Tourette Syndrome. 2022, 64-73. DOI: 10.4324/9780203822937-6.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeChronic ticsTS probandsGilles deFirst-degree relativesRelatives of probandsRelatives of controlsFamilies of probandsBiological relativesMorbid riskNormal subjectsNormal probandsFamilial disorderSyndromeProbandsCompulsive disorderFamily studiesTotal sampleDisordersPresent studyFurther evidenceRelativesPrevious studiesControl samples
2017
A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders
Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, Fernández de la Cruz L, Serlachius E, Leckman JF, Crowley JJ, Rück C, Almqvist C, Lichtenstein P, Larsson H. A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders. Molecular Psychiatry 2017, 23: 1652-1658. PMID: 29133949, PMCID: PMC5951741, DOI: 10.1038/mp.2017.215.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAutoimmune diseasesChronic tic disorderIndividual autoimmune diseasesThird-degree relativesTic disordersRisk of ADsNational Patient RegisterPatterns of comorbidityFirst-degree relativesPatient RegisterPlacental transmissionNationwide studyBirth cohortCTD casesFamilial clusteringDisordersComorbiditiesPopulation controlsProbandsOCD probandsBiological relativesDiseaseFamilial linkRiskDe Novo Coding Variants Are Strongly Associated with Tourette Disorder
Willsey AJ, Fernandez TV, Yu D, King RA, Dietrich A, Xing J, Sanders SJ, Mandell JD, Huang AY, Richer P, Smith L, Dong S, Samocha KE, Genetics T, Abdulkadir M, Bohnenpoll J, Bromberg Y, Brown L, Cheon K, Coffey B, Deng L, Dietrich A, Dong S, Elzerman L, Fernandez T, Fründt O, Garcia-Delgar B, Gedvilaite E, Gilbert D, Grice D, Hagstrøm J, Hedderly T, Heiman G, Heyman I, Hoekstra P, Hong H, Huyser C, Ibanez-Gomez L, Kim Y, Kim Y, King R, Koh Y, Kook S, Kuperman S, Lamerz A, Leventhal B, Ludolph A, da Silva C, Madruga-Garrido M, Mandell J, Maras A, Mir P, Morer A, Münchau A, Murphy T, Nasello C, Openneer T, Plessen K, Richer P, Roessner V, Sanders S, Shin E, Sival D, Smith L, Song D, Song J, State M, Stolte A, Sun N, Tischfield J, Tübing J, Visscher F, Walker M, Wanderer S, Wang S, Willsey A, Woods M, Xing J, Zhang Y, Zhou A, Zinner S, Genetics T, Barr C, Batterson J, Berlin C, Bruun R, Budman C, Cath D, Chouinard S, Coppola G, Cox N, Darrow S, Davis L, Dion Y, Freimer N, Grados M, Hirschtritt M, Huang A, Illmann C, Kurlan R, Leckman J, Lyon G, Malaty I, Mathews C, MaMahon W, Neale B, Okun M, Osiecki L, Pauls D, Posthuma D, Ramensky V, Robertson M, Rouleau G, Sandor P, Scharf J, Singer H, Smit J, Sul J, Yu D, Neale B, Coppola G, Mathews C, Tischfield J, Scharf J, State M, Heiman G. De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron 2017, 94: 486-499.e9. PMID: 28472652, PMCID: PMC5769876, DOI: 10.1016/j.neuron.2017.04.024.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingTourette's disorderDamaging variantsLikely gene-disrupting variantsComplex neurodevelopmental disorderClinical casesUnrelated probandsNeurodevelopmental disordersDe novo damaging variantsDisordersRisk genesGenetic cohortsConsistent evidenceCoding variantReplication sampleProbandsInternational ConsortiumCohortVariants
1995
A family study of obsessive-compulsive disorder
Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. American Journal Of Psychiatry 1995, 152: 76-84. PMID: 7802125, DOI: 10.1176/ajp.152.1.76.Peer-Reviewed Original ResearchConceptsFirst-degree relativesObsessive-compulsive disorderComparison subjectsSubthreshold obsessive-compulsive disorderAvailable first-degree relativesGilles de la Tourette's syndromeRelatives of probandsLa Tourette's syndromeFamily studiesBest-estimate diagnosesRate of ticsTic disordersFamily historyHigh riskTourette syndromeChronic ticsFemale probandsEarly onsetFamilial typeDisordersUnaffected subjectsProbandsSyndromeStructured interviewsSubjects
1991
A family study of Gilles de la Tourette syndrome.
Pauls DL, Raymond CL, Stevenson JM, Leckman JF. A family study of Gilles de la Tourette syndrome. American Journal Of Human Genetics 1991, 48: 154-63. PMID: 1985456, PMCID: PMC1682764.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeChronic ticsTS probandsGilles deFirst-degree relativesRelatives of probandsRelatives of controlsFamilies of probandsBiological relativesMorbid riskNormal subjectsNormal probandsFamilial disorderSyndromeProbandsCompulsive disorderFamily studiesTotal sampleDisordersPresent studyFurther evidenceRelativesPrevious studiesControl samples
1985
Depressives with secondary alcoholism: psychiatric disorders in offspring.
Merikangas KR, Weissman MM, Prusoff BA, Pauls DL, Leckman JF. Depressives with secondary alcoholism: psychiatric disorders in offspring. Journal Of Studies On Alcohol And Drugs 1985, 46: 199-204. PMID: 4010295, DOI: 10.15288/jsa.1985.46.199.Peer-Reviewed Original ResearchConceptsOffspring of probandsSecondary alcoholismMajor depressionGreater riskFivefold greater riskThreefold greater riskOffspring of controlsUnderlying illnessPsychiatric illnessPsychiatric disordersDepressed probandsAlcoholismAnxiety disordersDisordersDepressionFamilial aggregationProbandsRiskIllnessOffspringNumber of parentsAdditional increaseDepressive