2014
The Modulating Role of Stress in the Onset and Course of Tourette’s Syndrome
Buse J, Kirschbaum C, Leckman JF, Münchau A, Roessner V. The Modulating Role of Stress in the Onset and Course of Tourette’s Syndrome. Behavior Modification 2014, 38: 184-216. PMID: 24516255, DOI: 10.1177/0145445514522056.Peer-Reviewed Original ResearchConceptsTourette syndromePsychosocial stressActivation of HPAAdrenal axis activationExacerbation of ticsNoradrenergic neurotransmissionAxis activationHPA axisTic disordersTic exacerbationAberrant markersSyndromeNeurotransmissionModulating roleExacerbationPatientsUnderlying mechanismStrong activationImmunologyActivationCommon occurrenceSubsequent changesDopaminergicAbnormalitiesPathology
1999
Oxytocin, vasopressin, and autism: is there a connection?
Insel T, O’Brien D, Leckman J. Oxytocin, vasopressin, and autism: is there a connection? Biological Psychiatry 1999, 45: 145-157. PMID: 9951561, DOI: 10.1016/s0006-3223(98)00142-5.Peer-Reviewed Original ResearchConceptsVasopressin neurotransmissionAvailable preclinical evidencePreclinical evidenceClinical studiesAnimal studiesRodent brainPeptide receptorFeatures of autismOxytocinVasopressinGenetic disordersCompulsive behaviorsNeurotransmissionNormal expressionDevelopmental disordersSocial impairmentReceptorsCommunication deficitsDisordersSpecies-typical social behaviorsNeurobiological approachAutismEvidenceUnique effectsExpression