2022
Course of Tic Severity in Tourette Syndrome: The First Two Decades
Leckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. 2022, 80-85. DOI: 10.4324/9780203822937-8.Peer-Reviewed Original ResearchYears of ageDecades of lifeTic severityTourette syndromeTS patientsTic onsetClinical evaluationPrevalence studySeverity of ticsInitial clinical evaluationConsistent time courseTime courseHigh rateOnset of pubertyInitial followPatient's coursePrognostic valueYale Child Study CenterBirth-year cohortsPatientsNatural historySyndromeCurve analysisSeverityStudy centers
2017
Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS)
Leon J, Hommer R, Grant P, Farmer C, D’Souza P, Kessler R, Williams K, Leckman JF, Swedo S. Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). European Child & Adolescent Psychiatry 2017, 27: 637-643. PMID: 29119300, DOI: 10.1007/s00787-017-1077-9.Peer-Reviewed Original ResearchConceptsPediatric autoimmune neuropsychiatric disordersAutoimmune neuropsychiatric disordersIntravenous immunoglobulinStreptococcal infectionDose of IVIGNeuropsychiatric disordersPlacebo-controlled trialSignificant obsessive-compulsive symptomsPopulation of childrenCognitive behavioral therapySubacute illnessSydenham's choreaBlinded infusionChronic coursePsychiatric medicationsTreatment modalitiesSpecific symptomsChildhood-onset OCDLongitudinal courseNatural historyObsessive-compulsive symptomsBehavioral therapyExacerbationParents of participantsTelephone interviews
2013
Chapter Nine Neuroendocrine Aspects of Tourette Syndrome
Martino D, Macerollo A, Leckman JF. Chapter Nine Neuroendocrine Aspects of Tourette Syndrome. International Review Of Neurobiology 2013, 112: 239-279. PMID: 24295624, DOI: 10.1016/b978-0-12-411546-0.00009-3.Peer-Reviewed Original ResearchConceptsTourette syndromeObsessive-compulsive disorderStereotyped behaviorSubgroup of womenAction of testosteroneAnecdotal clinical evidenceDiurnal cortisol rhythmInjection of oxytocinStress steroid hormonesPreliminary evidenceAcute stress responseClinical evidenceAdrenal axisEstrogen levelsExogenous androgensGonadal hormonesCortisol rhythmNormal restorationAnimal modelsAndrogenic steroidsNeuroendocrine aspectsPatientsGender distributionBaseline activityNatural history
2006
Tourette Syndrome: The Self Under Siege
Leckman JF, Bloch MH, Scahill L, King RA. Tourette Syndrome: The Self Under Siege. Journal Of Child Neurology 2006, 21: 642-649. PMID: 16970864, DOI: 10.1177/08830738060210081001.Peer-Reviewed Original ResearchConceptsTourette syndromeAttention deficit hyperactivity disorderSensorimotor gatingSimple motor ticsYears of ageAge 10 yearsPostmortem brain studiesVivo brain imagingObsessive-compulsive disorderPrepubertal onsetVisual-motor integrationElectrophysiologic recordingsMotor ticsVocal ticsTic severityFine motorMost childrenNatural historySyndromeBehavioral treatmentMotor responseCourse of monthsNeural circuitryMotor integrationStereotyped movements
2005
Tourette syndrome and tic disorders: overview and practical guide to diagnosis and treatment.
Swain JE, Leckman JF. Tourette syndrome and tic disorders: overview and practical guide to diagnosis and treatment. Innov Clin Neurosci 2005, 2: 26-36. PMID: 21152158, PMCID: PMC3000195.Peer-Reviewed Original ResearchTourette syndromeObsessive-compulsive disorderNatural historyFirst-line optionCourse of illnessAlpha-adrenergic agentsComputerized literature searchAtypical neurolepticsTic disordersAccurate prognosticationAdrenergic agentsPathophysiological modelProper diagnosisHabit reversalSyndromeLiterature searchAnxiety disordersBehavioral interventionsImproved treatmentDisordersPatientsPractical reviewTreatmentDiagnosisAttention problems
2002
Development and natural history of mood disorders
Costello EJ, Pine DS, Hammen C, March JS, Plotsky PM, Weissman MM, Biederman J, Goldsmith HH, Kaufman J, Lewinsohn PM, Hellander M, Hoagwood K, Koretz DS, Nelson CA, Leckman JF. Development and natural history of mood disorders. Biological Psychiatry 2002, 52: 529-542. PMID: 12361667, DOI: 10.1016/s0006-3223(02)01372-0.Peer-Reviewed Original ResearchConceptsMood disordersMood disorders researchPediatric-onset bipolar disorderBipolar disorderUnipolar depressionNatural historySpecific risk factorsModel of pathogenesisPrecursor of depressionPsychotropic medicationsRisk infantsRisk factorsSuccessful treatmentHigh riskMultidisciplinary workgroupChildhood anxiety disordersJuvenile depressionDisorder researchEarly onsetProtective factorsAnxiety disordersPanel of expertsMental healthDisordersDepression
1983
Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research.
Leckman JF, Cohen DJ. Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research. Psychiatric Developments 1983, 1: 301-16. PMID: 6324164.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAttention Deficit Disorder with HyperactivityChildClonidineCompulsive BehaviorDopamineFemaleHaloperidolHomovanillic AcidHumansMaleObsessive BehaviorObsessive-Compulsive DisorderParasympathomimeticsPhysostigmineReceptors, AdrenergicSerotoninSex FactorsTic DisordersTourette SyndromeConceptsTourette syndromeGilles de la Tourette's syndromeDopamine receptor hypersensitivityLa Tourette's syndromeChronic multiple ticsWaning of symptomsComplex stereotypiesReceptor hypersensitivityNeurochemical disturbancesClinical presentationMetabolic findingsCSF HVAMotor involvementDopamine blockersTS patientsObsessive-compulsive behaviorClinical practiceMultiple ticsGilles deNatural historyRostrocaudal progressionFamilial aggregationSyndromeSymptomsDisorders