2022
Tourette's Syndrome: When Habit-Forming Systems Form Habits of Their Own?
Leckman J, Riddlet M. Tourette's Syndrome: When Habit-Forming Systems Form Habits of Their Own? 2022, 153-158. DOI: 10.4324/9780203822937-15.Peer-Reviewed Original Research
2010
Pathological laughter in Gilles de la Tourette syndrome: An unusual phonic tic
Cavanna AE, Ali F, Leckman JF, Robertson MM. Pathological laughter in Gilles de la Tourette syndrome: An unusual phonic tic. Movement Disorders 2010, 25: 2233-2239. PMID: 20683924, DOI: 10.1002/mds.23216.Peer-Reviewed Original ResearchConceptsPathological laughterPhonic ticsTourette syndromeGilles de la Tourette's syndromeLa Tourette's syndromeCase seriesPathophysiological mechanismsNeurological conditionsLimbic networkTic phenomenologyPremonitory urgesSignificant impairmentGilles deInappropriate outburstsPatientsSyndromeSymptomsSubjectsInappropriate behaviorImpairment
1995
A family study of obsessive-compulsive disorder
Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. American Journal Of Psychiatry 1995, 152: 76-84. PMID: 7802125, DOI: 10.1176/ajp.152.1.76.Peer-Reviewed Original ResearchConceptsFirst-degree relativesObsessive-compulsive disorderComparison subjectsSubthreshold obsessive-compulsive disorderAvailable first-degree relativesGilles de la Tourette's syndromeRelatives of probandsLa Tourette's syndromeFamily studiesBest-estimate diagnosesRate of ticsTic disordersFamily historyHigh riskTourette syndromeChronic ticsFemale probandsEarly onsetFamilial typeDisordersUnaffected subjectsProbandsSyndromeStructured interviewsSubjects
1993
Severe disturbances in speech, swallowing, and gait following stereotactic infrathalamic lesions in Gilles de la Tourette's syndrome.
Leckman JF, de Lotbinière A, Marek K, Gracco C, Scahill L, Cohen DJ. Severe disturbances in speech, swallowing, and gait following stereotactic infrathalamic lesions in Gilles de la Tourette's syndrome. Neurology 1993, 43: 890-4. PMID: 8492943, DOI: 10.1212/wnl.43.5.890.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeLa Tourette's syndromeLow-density areasMotor ticsTourette syndromeLast surgical procedureSevere gait disturbanceAnterior cingulate gyrusBilateral anterior cingulotomyGait disturbanceNeurologic deficitsObsessive-compulsive disorderSwallowing disordersAnterior cingulotomyPhonic ticsPostural instabilitySurgical proceduresCingulate gyrusObsessive-compulsive symptomsSyndromeNeurosurgical proceduresPatient's speechPatientsLesionsSecond procedure
1992
Sensory phenomena associated with Gilles de la Tourette's syndrome.
Cohen AJ, Leckman JF. Sensory phenomena associated with Gilles de la Tourette's syndrome. The Journal Of Clinical Psychiatry 1992, 53: 319-23. PMID: 1517194.Peer-Reviewed Original ResearchConceptsPremonitory urgesSyndrome AssociationPatient listsSensory phenomenaGilles de la Tourette's syndromeTourette Syndrome AssociationLa Tourette's syndromePhonic ticsVocal ticsTourette syndromeTS sufferersSyndromeVisual stimuliSubjectsSensitizationSufferersParticipantsTelephonePatientsUrgeCliniciansStudy
1991
Clonidine Treatment of Gilles de la Tourette's Syndrome
Leckman JF, Hardin MT, Riddle MA, Stevenson J, Ort SI, Cohen DJ. Clonidine Treatment of Gilles de la Tourette's Syndrome. JAMA Psychiatry 1991, 48: 324-328. PMID: 2009034, DOI: 10.1001/archpsyc.1991.01810280040006.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeLa Tourette's syndromeClonidine treatmentTourette syndromeTic severityDouble-blind clinical trialMotor tic severityClinical trialsClonidine hydrochlorideBehavioral symptomsClinical ratingsSyndromeMagnitude of responseClonidineTreatmentParent-rated measuresSeveritySubjectsPlaceboVideotaped interviewGroupSymptomsCliniciansHyperactivityTrials
1990
Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis.
Leckman JF, Chittenden EH. Gilles de La Tourette's syndrome and some forms of obsessive-compulsive disorder may share a common genetic diathesis. L Encéphale 1990, 16 Spec No: 321-3. PMID: 2209489.Peer-Reviewed Original ResearchConceptsPathophysiology of TSGilles de la Tourette's syndromeObsessive-compulsive disorderLa Tourette's syndromeTourette syndromeOCD patientsCerebrospinal fluid studiesRecent neuropathological studiesEndogenous opioid peptidesMesocortical dopaminergic systemCases of OCDCSF dynorphinNeuropathological studiesCommon genetic diathesisRaphe nucleusBasal gangliaSerotoninergic systemSerotonergic systemClinical studiesDopaminergic systemCommon neural substrateTS patientsNeuropharmacological studiesOpioid peptidesNormal controls
1988
Elevated CSF dynorphin A [1–8] in Tourette's syndrome
Leckman JF, Riddle MA, Berrettini WH, Anderson GM, Hardin M, Chappell P, Bissette G, Nemeroff CB, Goodman WK, Cohen DJ. Elevated CSF dynorphin A [1–8] in Tourette's syndrome. Life Sciences 1988, 43: 2015-2023. PMID: 2463450, DOI: 10.1016/0024-3205(88)90575-9.Peer-Reviewed Original ResearchConceptsPathobiology of TSTourette syndromeNeuroanatomic distributionEndogenous opioidsNeuropathological studiesObsessive-compulsive disorderPrevalence of TSBehavioral effectsPost-mortem brain studiesPathophysiology of TSGilles de la Tourette's syndromeCentral dopaminergic neuronsRecent neuropathological studiesLevels of dynorphinSevere Tourette syndromeBasal ganglia structuresChronic neuropsychiatric disorderLa Tourette's syndromeCentral monoaminergicCSF dynorphinElevated CSFStriatal fibersCSF studiesDopaminergic neuronsBasal ganglia
1985
Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective.
Leckman J, Detlor J, Harcherik D, Ort S, Shaywitz B, Cohen D. Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective. Neurology 1985, 35: 343-51. PMID: 3883235, DOI: 10.1212/wnl.35.3.343.Peer-Reviewed Original ResearchConceptsTourette syndromeGilles de la Tourette's syndromePlacebo-controlled trialDouble-blind studyLong-term treatmentSerious side effectsLa Tourette's syndromeUnequivocal respondersPhonic ticsClonidineSide effectsSyndromeDrug efficacyEquivocal responseClinical perspectivePatientsEfficacyBehavior problemsSignificant improvementRespondersTrialsWeeks
1983
Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research.
Leckman JF, Cohen DJ. Recent advances in Gilles de la Tourette syndrome: implications for clinical practice and future research. Psychiatric Developments 1983, 1: 301-16. PMID: 6324164.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAttention Deficit Disorder with HyperactivityChildClonidineCompulsive BehaviorDopamineFemaleHaloperidolHomovanillic AcidHumansMaleObsessive BehaviorObsessive-Compulsive DisorderParasympathomimeticsPhysostigmineReceptors, AdrenergicSerotoninSex FactorsTic DisordersTourette SyndromeConceptsTourette syndromeGilles de la Tourette's syndromeDopamine receptor hypersensitivityLa Tourette's syndromeChronic multiple ticsWaning of symptomsComplex stereotypiesReceptor hypersensitivityNeurochemical disturbancesClinical presentationMetabolic findingsCSF HVAMotor involvementDopamine blockersTS patientsObsessive-compulsive behaviorClinical practiceMultiple ticsGilles deNatural historyRostrocaudal progressionFamilial aggregationSyndromeSymptomsDisorders