2022
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Brady M, Mariani J, Koca Y, Szekely A, King R, Bloch M, Landeros-Weisenberger A, Leckman J, Vaccarino F. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular Psychiatry 2022, 27: 5007-5019. PMID: 36447010, PMCID: PMC9949887, DOI: 10.1038/s41380-022-01880-5.Peer-Reviewed Original ResearchConceptsTourette syndromeInterneuron deficitsGABAergic interneuronsHealthy controlsNeurodevelopmental underpinningsNeuropathological deficitsBG circuitryNeuropsychiatric disordersDecreased differentiationT patientsInterneuronsAltered expressionPotential mechanismsCilia disruptionSonic hedgehogOrganoidsStem cellsTS individualsPluripotent stem cellsGli transcription factorsDeficitsOrganoid differentiationEarly stagesCholinergicPatients
2020
An examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome
Yildirim Z, Karabekiroglu K, Yildiran A, Celiksoy MH, Artukoglu B, Baykal S, Babadağı Z, Leckman J. An examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome. Nordic Journal Of Psychiatry 2020, 75: 18-24. PMID: 32580599, DOI: 10.1080/08039488.2020.1779808.Peer-Reviewed Original ResearchConceptsTS/chronic tic disorderChronic tic disorderSex-matched healthy controlsModerate-severe groupHealthy controlsLymphocyte countTourette syndromeLymphocyte percentagePatient groupTic disordersHC groupControl groupT-helper lymphocyte countYale Global Tic Severity ScaleT helper (TH) (CD4) numberT-lymphocyte countsT lymphocyte numbersT-lymphocyte percentageRegulatory T cellsT cell valuesTic Severity ScaleTreg percentageChildhood-onset neurodevelopmental disorderLymphocyte numbersPhonic ticsAutoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections
Chain JL, Alvarez K, Mascaro-Blanco A, Reim S, Bentley R, Hommer R, Grant P, Leckman JF, Kawikova I, Williams K, Stoner JA, Swedo SE, Cunningham MW. Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections. Frontiers In Psychiatry 2020, 11: 564. PMID: 32670106, PMCID: PMC7328706, DOI: 10.3389/fpsyt.2020.00564.Peer-Reviewed Original ResearchPediatric autoimmune neuropsychiatric disordersAnti-neuronal autoantibodiesSerum autoantibody titersAutoimmune neuropsychiatric disordersSydenham's choreaAutoantibody titersEnzyme-linked immunosorbent assayCerebrospinal fluidNeuronal autoantigensNeuropsychiatric disordersPANDAS patientsPANDAS subjectsStreptococcal infectionHealthy controlsAcute symptomatic phaseBasal ganglia encephalitisGroup of autoantibodiesHealthy control subjectsCaMKII activationAttention deficit hyperactivity disorderHuman neuronal cellsDeficit hyperactivity disorderGroup of childrenAutoantibody biomarkersObsessive-compulsive disorder
2019
Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD
Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Psychiatry Research 2019, 278: 248-257. PMID: 31233935, PMCID: PMC6637759, DOI: 10.1016/j.psychres.2019.06.021.Peer-Reviewed Original ResearchConceptsBehavioral measuresAttentional controlIntegrated brainGo/No-Go taskGo-P3 latencySlower reaction timesSocial interventionsRobust treatment effectAttentional systemADHD groupERP measuresDifference waveP3 latencyBrain activityADHDTAU groupEEG proceduresHealthy controlsHC groupReaction timeReplication purposesERPTreatment effectsChildrenSecondary goal
2017
Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum
Frick L, Rapanelli M, Jindachomthong K, Grant P, Leckman JF, Swedo S, Williams K, Pittenger C. Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum. Brain Behavior And Immunity 2017, 69: 304-311. PMID: 29233751, PMCID: PMC5857467, DOI: 10.1016/j.bbi.2017.12.004.Peer-Reviewed Original ResearchConceptsGroup A beta-hemolytic streptococciCholinergic interneuronsPediatric Autoimmune Neuropsychiatric Disorder AssociatedNeuropsychiatric Disorder AssociatedStriatal cholinergic interneuronsStriatum of miceBeta-hemolytic streptococciBrain antigensPANDAS patientsIntravenous immunoglobulinStriatal interneuronsNeuropsychiatric symptomsObsessive-compulsive disorderSymptom improvementGABAergic interneuronsClinical trialsHealthy controlsDisorders AssociatedTic disordersChildhood onsetInterneuronsLocus of pathologyElevated bindingAntibodiesStriatum
2013
Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingHealthy subjectsTic severityWhole-brain functional magnetic resonance imagingYale Global Tic Severity ScaleTactile startle responseCase-control study designTic Severity ScaleCortical-striatal circuitsBrain activityMagnetic resonance imagingMultiple brain regionsLeft middle frontal gyrusMiddle frontal gyrusDegree of PPIPulse-alone stimuliBlock-design fMRI paradigmTic symptomsNeuropathological dataHealthy controlsPrepulse inhibitionDevelopmental neuropsychiatric disordersSensorimotor gatingLeft caudate
2011
Risperidone-Related Improvement of Irritability in Children with Autism Is not Associated with Changes in Serum of Epidermal Growth Factor and Interleukin-13
Tobiasova Z, van der Lingen KH, Scahill L, Leckman JF, Zhang Y, Chae W, McCracken JT, McDougle CJ, Vitiello B, Tierney E, Aman MG, Arnold LE, Katsovich L, Hoekstra PJ, Volkmar F, Bothwell AL, Kawikova I. Risperidone-Related Improvement of Irritability in Children with Autism Is not Associated with Changes in Serum of Epidermal Growth Factor and Interleukin-13. Journal Of Child And Adolescent Psychopharmacology 2011, 21: 555-564. PMID: 22070180, PMCID: PMC3279715, DOI: 10.1089/cap.2010.0134.Peer-Reviewed Original ResearchConceptsMedication-free subjectsEpidermal growth factorHealthy controlsInflammatory markersIL-13IL-1 receptor antagonistGrowth factorSerum inflammatory markersChemoattractant protein-1Placebo groupClinical improvementBaseline visitIL-17Serum levelsCytokine concentrationsInflammatory moleculesSerum concentrationsClinical trialsHealthy subjectsIL-1Interleukin-13RisperidoneAltered levelsProtein 1Diagnosis of autism
2010
Altered immunoglobulin profiles in children with Tourette syndrome
Bos-Veneman NG, Olieman R, Tobiasova Z, Hoekstra PJ, Katsovich L, Bothwell AL, Leckman JF, Kawikova I. Altered immunoglobulin profiles in children with Tourette syndrome. Brain Behavior And Immunity 2010, 25: 532-538. PMID: 21156204, PMCID: PMC3056238, DOI: 10.1016/j.bbi.2010.12.003.Peer-Reviewed Original ResearchConceptsTourette syndromeSymptom exacerbationHealthy controlsSymptom severityPost-infectious autoimmunityB cell immunityLevels of IgG2Independent cross-sectional samplesCell immunitySerum levelsAdditional patientsIgG3 levelsIgM levelsImmunoglobulin profileHealthy childrenImmune deficiencyTrend-level significanceHealthy subjectsSerum IgG3PatientsIg profilesCross-sectional sampleIgG3Time pointsIg concentrations
2001
Regional Brain and Ventricular Volumes in Tourette Syndrome
Peterson BS, Staib L, Scahill L, Zhang H, Anderson C, Leckman JF, Cohen DJ, Gore JC, Albert J, Webster R. Regional Brain and Ventricular Volumes in Tourette Syndrome. JAMA Psychiatry 2001, 58: 427-440. PMID: 11343521, DOI: 10.1001/archpsyc.58.5.427.Peer-Reviewed Original ResearchConceptsParieto-occipital regionsTourette syndromeTic symptomsCerebral volumeVentricular volumePathophysiology of TST subjectsWhite matter portionsThalamo-cortical circuitrySignificant inverse associationRegional cerebral volumesHigh-resolution anatomical magnetic resonance imagesStandard anatomical landmarksSex differencesAge-related findingsDorsal prefrontal regionsRegional brainCortico-striatoHealthy childrenHealthy controlsInverse associationHealthy subjectsOccipital volumeTS groupCortical regions