2020
Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling
Heiman GA, Rispoli J, Seymour C, Leckman JF, King RA, Fernandez TV. Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling. Frontiers In Neurology 2020, 11: 770. PMID: 32849224, PMCID: PMC7432137, DOI: 10.3389/fneur.2020.00770.Peer-Reviewed Original ResearchChronic tic disorderRecurrence risk estimatesTic disordersRecurrence riskTourette's disorderRisk estimatesNeuropsychiatric disordersPopulation-based family studyGenetic counselingFirst-degree relativesQuality of lifeFamily studiesVocal ticsPopulation prevalenceFamilial recurrence riskSuch counselingGenetic testingDisordersRiskCounselingEmpiric recurrence riskGenetic variantsRange of risksHeterogeneous genetic architectureComorbiditiesAn examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome
Yildirim Z, Karabekiroglu K, Yildiran A, Celiksoy MH, Artukoglu B, Baykal S, Babadağı Z, Leckman J. An examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome. Nordic Journal Of Psychiatry 2020, 75: 18-24. PMID: 32580599, DOI: 10.1080/08039488.2020.1779808.Peer-Reviewed Original ResearchConceptsTS/chronic tic disorderChronic tic disorderSex-matched healthy controlsModerate-severe groupHealthy controlsLymphocyte countTourette syndromeLymphocyte percentagePatient groupTic disordersHC groupControl groupT-helper lymphocyte countYale Global Tic Severity ScaleT helper (TH) (CD4) numberT-lymphocyte countsT lymphocyte numbersT-lymphocyte percentageRegulatory T cellsT cell valuesTic Severity ScaleTreg percentageChildhood-onset neurodevelopmental disorderLymphocyte numbersPhonic tics
2017
A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders
Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, Fernández de la Cruz L, Serlachius E, Leckman JF, Crowley JJ, Rück C, Almqvist C, Lichtenstein P, Larsson H. A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders. Molecular Psychiatry 2017, 23: 1652-1658. PMID: 29133949, PMCID: PMC5951741, DOI: 10.1038/mp.2017.215.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAutoimmune diseasesChronic tic disorderIndividual autoimmune diseasesThird-degree relativesTic disordersRisk of ADsNational Patient RegisterPatterns of comorbidityFirst-degree relativesPatient RegisterPlacental transmissionNationwide studyBirth cohortCTD casesFamilial clusteringDisordersComorbiditiesPopulation controlsProbandsOCD probandsBiological relativesDiseaseFamilial linkRiskTemporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study
Leslie DL, Kobre RA, Richmand BJ, Guloksuz S, Leckman JF. Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study. Frontiers In Psychiatry 2017, 8: 3. PMID: 28154539, PMCID: PMC5244035, DOI: 10.3389/fpsyt.2017.00003.Peer-Reviewed Original ResearchObsessive-compulsive disorderAnorexia nervosaNeuropsychiatric disordersPrior vaccinationPilot case-control studyAnxiety disordersConditional logistic regression modelsClear public health benefitsVaccination of childrenCase-control studyChronic tic disorderMajor depressive disorderChildhood infectious diseasesCertain neuropsychiatric disordersAttention deficit hyperactivity disorderPublic health benefitsLogistic regression modelsAntecedent administrationAntecedent infectionAntecedent vaccinationDeficit hyperactivity disorderInfluenza vaccinationVaccination scheduleIncident diagnosisCDC guidelines
2016
Understanding the covariation of tics, attention‐deficit/hyperactivity, and obsessive‐compulsive symptoms: A population‐based adult twin study
Pinto R, Monzani B, Leckman JF, Rück C, Serlachius E, Lichtenstein P, Mataix‐Cols D. Understanding the covariation of tics, attention‐deficit/hyperactivity, and obsessive‐compulsive symptoms: A population‐based adult twin study. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 171: 938-947. PMID: 26919823, DOI: 10.1002/ajmg.b.32436.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivityObsessive-compulsive symptomsObsessive-compulsive disorderTic disordersChronic tic disorderAttention-deficit/hyperactivity symptomsSwedish adult twinsNon-shared environmental influencesPopulation-representative sampleLarge population-representative sampleSymptomsSpecific non-shared environmental influencesEnvironmental influencesFamilial associationSymptom subtypesEpidemiological sampleHyperactivity symptomsHyperactivityFamilial transmissionDisordersEtiological influencesLiability factorsFamily studiesGenetic liability
2015
Familial Risks of Tourette Syndrome and Chronic Tic Disorders: A Population-Based Cohort Study
Mataix-Cols D, Isomura K, Pérez-Vigil A, Chang Z, Rück C, Larsson KJ, Leckman JF, Serlachius E, Larsson H, Lichtenstein P. Familial Risks of Tourette Syndrome and Chronic Tic Disorders: A Population-Based Cohort Study. JAMA Psychiatry 2015, 72: 787-793. PMID: 26083307, DOI: 10.1001/jamapsychiatry.2015.0627.Peer-Reviewed Original ResearchConceptsChronic tic disorderFirst-degree relativesTic disordersTourette syndromeFamilial riskSwedish National Patient RegisterNational Patient RegisterSecond-degree relativesRelatives of probandsPopulation-based twin sampleThird-degree relativesFamily studiesCohort studyPatient RegisterFemale patientsSpecialist clinicMAIN OUTCOMESimilar riskGeneral populationPopulation cohortHeritable neuropsychiatric conditionsNeuropsychiatric conditionsSimilar environmental exposuresEnvironmental exposuresDisorders
2012
Systematic review: Pharmacological treatment of tic disorders – Efficacy of antipsychotic and alpha-2 adrenergic agonist agents
Weisman H, Qureshi IA, Leckman JF, Scahill L, Bloch MH. Systematic review: Pharmacological treatment of tic disorders – Efficacy of antipsychotic and alpha-2 adrenergic agonist agents. Neuroscience & Biobehavioral Reviews 2012, 37: 1162-1171. PMID: 23099282, PMCID: PMC3674207, DOI: 10.1016/j.neubiorev.2012.09.008.Peer-Reviewed Original ResearchTourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder
Lebowitz ER, Motlagh MG, Katsovich L, King RA, Lombroso PJ, Grantz H, Lin H, Bentley MJ, Gilbert DL, Singer HS, Coffey BJ, the Tourette Syndrome Study Group, Kurlan RM, Leckman JF. Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 2012, 21: 451-457. PMID: 22543961, PMCID: PMC3722559, DOI: 10.1007/s00787-012-0278-5.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderComorbid tic disordersObsessive-compulsive disorderSeverity of ticsChronic tic disorderTic disordersPsychosocial stressDeficit hyperactivity disorderGlobal functioningComorbid diagnosesHyperactivity disorderMore severe ticsComorbid attention deficit hyperactivity disorderDiagnosis of OCDComorbid obsessive-compulsive disorderAdditional comorbid diagnosesSymptoms of anxietyHigh psychosocial stressMore internalizing disordersGreater psychosocial stressSevere ticsOppositional defiant disorderSevere subtypeTic severityTourette syndrome
2008
Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements
Hampson M, Tokoglu F, King RA, Constable RT, Leckman JF. Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements. Biological Psychiatry 2008, 65: 594-599. PMID: 19111281, PMCID: PMC2679868, DOI: 10.1016/j.biopsych.2008.11.012.Peer-Reviewed Original ResearchConceptsMotor cortexSupplementary motor areaControl subjectsBrain areasMotor ticsTic disordersTic movementsMotor areaTic-like movementsHealthy control subjectsChronic tic disorderNormal control subjectsChronic motor ticsNovel intervention strategiesFunctional neuroimaging studiesTic executionSevere ticsIntentional movementPatient's ticsMotor regionsPremonitory urgesBrain activity patternsAdult subjectsTic generationCortex
2005
A family study of early‐onset obsessive‐compulsive disorder
do Rosario‐Campos M, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL. A family study of early‐onset obsessive‐compulsive disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 92-97. PMID: 15892140, DOI: 10.1002/ajmg.b.30149.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRecurrence riskChronic ticsFirst-degree family membersChildhood-onset obsessive-compulsive disorderDiagnosis of OCDChronic tic disorderStandardized semi-structured interviewFirst-degree relativesEarly-onset casesOnset obsessive-compulsive disorderDSM-IV criteriaEarly-onset obsessive-compulsive disorderBest-estimate processRandom digit dialingHigh comorbid ratesAge of onsetFamily studiesHigh genetic loadingMean ageSpecialty clinicTic disordersComorbid ratesValid subgroupsCase relatives
1995
Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: three cases.
McDougle CJ, Fleischmann RL, Epperson CN, Wasylink S, Leckman JF, Price LH. Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: three cases. The Journal Of Clinical Psychiatry 1995, 56: 526-8. PMID: 7592506.Peer-Reviewed Original ResearchConceptsSerotonin uptake inhibitorObsessive-compulsive disorderY-BOCS scoresYale-Brown Obsessive Compulsive ScaleRisperidone additionOCD patientsComorbid chronic tic disorderPatients' Y-BOCS scoresRefractory obsessive-compulsive disorderOpen-label mannerLow-dose haloperidolSide effect profileWeeks of treatmentChronic tic disorderEffective treatment strategiesObsessive Compulsive ScaleSUI treatmentEffect profileNeuroleptic treatmentTardive dyskinesiaTypical neurolepticsModerate sedationReceptor antagonistTic disordersTreatment strategies
1994
Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder: A Double-blind, Placebo-Controlled Study in Patients With and Without Tics
McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH. Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder: A Double-blind, Placebo-Controlled Study in Patients With and Without Tics. JAMA Psychiatry 1994, 51: 302-308. PMID: 8161290, DOI: 10.1001/archpsyc.1994.03950040046006.Peer-Reviewed Original ResearchConceptsComorbid chronic tic disorderChronic tic disorderYale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderTic disordersFluvoxamine treatmentOCD patientsClinical Global Impression ScalePlacebo-treated groupDouble-blind fashionWeeks of treatmentGlobal Impression ScaleTreatment of patientsHaloperidol-treated groupEffective symptom reductionObsessive Compulsive ScaleNeuroleptic therapyBlood levelsImpression ScaleTreatment outcomesTreatment responseAdequate treatmentPatientsPlaceboSymptom reduction